What is Levothyroxine?

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  • Written By: K. Willis
  • Edited By: C. Wilborn
  • Last Modified Date: 29 November 2019
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Levothyroxine is a synthetic replacement for thyroxine, a hormone normally produced in the thyroid gland. It is used to treat hypothyroidism, which is caused when the body does not produce enough of this hormone. Levothyroxine is most commonly administered in tablet form, but is also available in liquid form.

The most common symptoms of hypothyroidism include depression, dry or thickened skin, slowed speech, and fluid retention. General, diffuse aches and pains are a common symptom, as are muscle cramps, lethargy, and loss of stamina. Less common symptoms can include memory loss, infertility, irregular or heavy menstruation, and a hoarse voice.

Levothyroxine is usually taken in the morning in one single daily dose before eating, but the dosage and timing should be determined by a healthcare professional. The usual dose varies between 50 and 150 micrograms per day for adults, with a lower dose usually prescribed to begin treatment. It can take six to eight weeks for the patient to see a significant improvement in his or her condition. It is important not to take iron, calcium or aluminum containing medications at the same time as this medication.

Except in rare circumstances, levothyroxine will most often need to be taken for life. Occasionally, hypothyroidism will develop within six months of giving birth, but thyroxine hormone levels will usually quickly return to a normal levels. Occasionally, older children develop short-term hypothyroidism, which often requires short-term levothyroxine treatment.


Reported side effects include weight gain, nausea, headaches, and diarrhea, as well as rapid heartbeat. Allergic reactions have also been reported in some patients. If a patient suffers from any adverse effects, the medication should be stopped immediately and his or her medical professional should be consulted. Some patients have found that natural thyroxine replacement works better than levothyroxine.

Desiccated porcine thyroxine is basically the natural dried thyroxine of pigs. Some patients and patient advocacy groups claim that may people receive more benefits and fewer side effects from this natural hormone than synthesized levothyroxine. If a patient is planning to self-administer desiccated porcine thyroxine, the dosage must be carefully calculated to avoid consuming too much, which causes a range of health problems. As with levothyroxine, the dose of natural porcine thyroxine should be started at a low level, and increased slowly at two to three week intervals.


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