What is Hesperidin?

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  • Written By: J.S. Metzker Erdemir
  • Edited By: Bronwyn Harris
  • Last Modified Date: 14 February 2020
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Hesperidin is a flavonoid found in the rinds of citrus fruits. Flavonoids are a type of polyphenol, which are antioxidants found in plants and are essential to human health. Hesperidin is one of the flavonoids that give citrus fruits their color and taste. It is also sold as a health supplement to repair and prevent damage from cardiovascular degeneration and disease.

Hesperidin is also referred to by names like bioflavonoid, citrus bioflavonoid, and hesperin methyl-chalcone. It is often present in multi-vitamins, though it can also be found as a pure extract. It is so abundant in citrus fruits that it is an inexpensive by-product of citrus production, and adequate amounts of the flavonoid can usually be obtained by eating citrus fruits and drinking citrus juices with pulp.

Flavonoids like hesperidin used to be called “vitamin P.” This term is now obsolete, but flavonoids and vitamins are essential to each other. Hesperidin is most commonly found in foods that are high in vitamin C, and it is an essential component in vitamin C absorption. Vitamin C actually consists of a chain of molecules, so flavonoids complete the chain and make the vitamin more soluble for easy absorption into the body. People with vitamin absorption disorders, such as those with elevated levels of copper in the blood, often benefit from taking hesperidin supplements along with extra Vitamin C.


In addition to its antioxidant properties, hesperidin can also be used as an anti-inflammatory and anti-carcinogenic compound. It seems to reduce the symptoms of allergies and hay fever by inhibiting histamine production in the blood, and early clinical trials with female mice showed that this antioxidant decreased the bone loss associated with aging.

In clinical tests, hesperidin taken as a supplement has shown promising results in increasing the strength and elasticity of vascular walls. It can also reduce or slow vascular degeneration associated with liver disease, aging, and lack of exercise. Hesperidin increases blood flow and helps reduce problems associated with vascular swelling such as hemorrhoids and varicose veins. Like other polyphenols, such as the compounds found in olive oil, hesperidin can be used to reduce cholesterol levels in the blood.

It is safe for most people to take hesperidin supplements. Some people, especially those who are allergic to citrus fruits, might have a reaction to the compound. Pregnant women, nursing mothers, and people taking blood thinners should not use hesperidin supplements without professional guidance.


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Post 3

Hesperidin sounds complex! Wonderfully complex, considering its ability to be an anti-inflammatory and anti-carcinogenic compound that can also be a cholesterol reducer!

I had a friend who told my husband and I that there was good stuff in the orange rind. However, she could not recall what it was called - now I will be able to fill her in on what it is called and all of the positives that it provides.

I am not a fan of the pulp in my orange juice, but a bit of orange or lemon zest in some of my recipes will be a great addition (to the recipe and my health apparently).

Post 2

I have read that a lack of hesperidin can cause weakness and aches in the legs and arms, as well as leg cramps in the middle of the night. I discovered this as I was looking for a way to prevent the terrible calf cramps that were waking me up in the early hours of the morning.

I read that tangelos are one of the richest sources of hesperidin. So, I started eating them. I eat the membrane as well, because that is where the hesperidin lies. I also drink orange juice with heavy pulp.

My leg cramps have stopped. I will keep eating and drinking sources of hesperidin, because I would hate for them to return.

Post 1

I always noticed that after eating an orange, my sinuses seemed to temporarily clear up. I assumed that this was because of the strong scent of the fruit, but after reading this, I think that maybe the hesperidin in the orange acted as an antihistamine.

It’s neat how an orange contains both vitamin C and something to make your body better absorb vitamin C. Hesperidin is probably responsible for the positive effects of vitamin C on the immune system.

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