What is a CD34 Antibody?

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  • Written By: Jason C. Chavis
  • Edited By: Bronwyn Harris
  • Last Modified Date: 06 September 2019
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A CD34 antibody is a human cellular molecule responsible for a number of different functions within the body. Located on the surface of the cell, the antibody acts as either a receptor or a ligand. As a receptor, the CD34 antibody is found within the plasma membrane or cytoplasm of a cell and signals other cells to perform certain actions. When it takes on the role of a ligand, it merely bonds other receptors together. The process by which scientists determine the antibody's actual function defines the molecule as a cluster of differentiation (CD), a protocol for measuring the CD34.

Most of the time, the CD34 antibodies are considered to be adhesive elements that bond different cells together. This is accomplished due to the fact that the CD34 antibody is a glycoprotein, a protein that covalently attaches different polypeptide chains to one another through carbohydrates, known as the process of glycosylation. Some of these attachments can extend from the cellular surface and interact with other cells themselves in the transfer of information, specifically the encoding for the human gene of the same name.


As one of many research antibodies investigated for its full utilization within the human body, the CD34 antibody has been shown to maintain a number of different functions in our general well-being. Its primary function in the immune system is as the mediator to connective tissue known as stromal cells. This is seen most commonly in the region connecting bone marrow and stem cells. Due to its presence in bone marrow, scientists believe it has a fundamental correlation between the production of the immunity elements within the blood and the T cells' ability to enter lymphatic vessels.

In order for an antibody production company to separate the CD34 antibody from antigens on the surface of the cell, the CD process must take place. This can be accomplished through various identification techniques using blood samples. One of the most common practices is known as immunomagnetics, in which cell populations are separated using magnetic beads that attach to the cells. Immuofluorescent technology can also be utilized to identify the CD34 antibody. Also known as flow cytometry, this process uses fluorescent proteins attached to the cellular membrane with the goal of identifying potential antibodies in an apparatus that electronically detects their presence.

One of the most common uses for the CD34 antibody is to purify replicas of stem cells. When researchers clone stem cells for use in labs and studies, specifically those involving blood systems, the CD34 helps establish a clear way for the cells to bond with other cells. This is extremely helpful in situations involving bone marrow transplants.


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