What Are the Pros and Cons of a Bone Marrow Transplant for Leukemia?

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  • Written By: Amy Hunter
  • Edited By: Andrew Jones
  • Last Modified Date: 11 May 2020
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A bone marrow transplant for leukemia is an effective treatment, either curing the disease or extending the time that a patient lives disease free. While the effectiveness of the procedure cannot be denied, it is an invasive medical procedure with a long list of complications and side effects. It is important to discuss all options with a physician before deciding on a bone marrow transplant.

There are two different periods where complications can develop during a bone marrow transplant for leukemia. During the actual infusion process, it is common for the patient to experience hives, fever, chills, and pain. During the recovery period, the patient may also develop mouth sores, be extremely weak, develop nausea and diarrhea, and go through periods of confusion and emotional distress. The recovery period of a bone marrow transplant for leukemia includes weeks of staying in the hospital, extreme vulnerability to infection, the need for blood transfusions, and the requirement to stay in a sterile environment.

Complications that can arise include infections, low platelets and low red blood cell counts, fluid overload, respiratory distress, mouth pain, gastrointestinal pain, organ damage, graft failure and graft versus host disease. The side effects of these complications can be anything from discomfort to death. Graft failure develops when the immune system destroys the new bone marrow, leading to graft rejection. Graft versus host disease develops when the genetic material of the transplanted bone marrow is not close enough to the patient's genetic material, causing the body to treat the new bone marrow as a foreign body.

Leukemia is typically treated with chemotherapy. A bone marrow transplant for leukemia is typical if the patient has been in remission, but relapses or has leukemia that is refractory, or resistant to treatment. Relapsed or refractory leukemia may also be treated with radiation.

Three different types of bone marrow transplants exist: autologous, allogeneic, and syngeneic. Autologous procedures are rarely used for patients with leukemia. In an autologous bone marrow transplant, the patient donates his or her own bone marrow. A syngeneic transplant is bone marrow that is taken from an identical twin.

The final and most common type of bone marrow transplant for leukemia is the allogeneic transplant. This bone marrow comes from a donor, often a sibling or other family member other than an identical twin, although it can also come from a stranger. Blood tests are used to determine if the genetic material is a close enough match to make the person a good choice as donor.

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Post 3

A former co-worker had a bone marrow transplant to treat leukemia and she said by far the worst part was having the radiation to kill the bone marrow to start with. She said that was worse than any of the other side effects.

She said the sores in her mouth were awful, her skin was dry from the radiation and because her resistance was so low, she had to stay in an isolation unit in the hospital, just to stay alive until she got the transplant done. Then, she had to stay another six weeks or so until the marrow was established in her body and she had an immune system again. She said if she relapsed she wasn't sure if she could go through the process again.

Post 2

My dad was an identical twin, so if I ever need a bone marrow transplant (God forbid!), I have a sister and two female cousins who might very well be matches.

Whether doctors consider a bone marrow transplant also depends on what kind of leukemia the patient has. If they have a kind that is particularly difficult to treat successfully, with chemotherapy and radiation then, if a match can be found, a transplant may be the only way the person can survive the disease.Some types of leukemia, even if they are not relapses, do not respond to the more go-to methods, so a doctor may want to do a bone marrow transplant.

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