What Is Tissue Homeostasis?

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  • Written By: Andrew Kirmayer
  • Edited By: Shereen Skola
  • Last Modified Date: 17 September 2019
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To function normally, the different types of tissues and organs in the body need to work consistently regardless of external conditions. Damage from injuries and normal functions can be repaired as part of the body’s chemistry. Optimal health is generally dependent upon tissue homeostasis, which may be regulated by genetics as well as molecular processes in cells. The process is regulated by genes and possibly stem cells, which some researchers believe can differentiate into organ tissues that need to be repaired. Tissue homeostasis typically involves consistency in the content of blood, in coordination of organ activity, and in normal cell function.

Body functions are usually affected by activities that occur at the molecular level. Molecules called glycosaminoglycans (GAGs) can play a role in the structure of cellular elements, and often regulate activity in cells. These functions are usually controlled by the interaction of GAGs with other proteins, which can include various enzymes, growth factor compounds, receptors, as well as molecules that allow proteins to adhere to one another. Various processes are often responsible for regulating the function and structure of compounds, as well as interactions between them. When all of these are regulated, then tissue homeostasis is generally maintained.


Homeostasis in the body typically relies on an internal equilibrium that is maintained regardless of environmental factors such as temperature. Processes that can trigger aging, neurological degeneration, cell death, and disrupt wound healing often cause tissue homeostasis to be thrown off balance. Many neurological and cardiovascular diseases may arise out of an imbalance of the body’s regulatory functions.

The internal environment of the body is usually controlled molecularly, by blood composition, and the presence of normal levels of fluid between tissues. Healthy neurological activity and control by the endocrine system typically helps regulate the activity of organs and complete systems. The body is generally made up of elements such as epithelial linings and connective, muscular, and nervous tissue. Organ and organ system function are usually important for tissue homeostasis as well as the fluid composition and structure of body cavities.

Tissue homeostasis can also depend on the maintenance of body functions like digestion, respiration, urination, and lymphatic control. The health of the skin is typically important, along with normal skeletal support, muscle movement, and responses between the nervous system and muscles. Some researchers also believe that stem cells can renew themselves to maintain tissues. The mechanisms involved in activating these cells can be involved in controlling and restoring tissue homeostasis.


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