What Is the Relationship between Sertraline and ADHD?

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  • Written By: Jennifer Voight
  • Edited By: Melissa Wiley
  • Last Modified Date: 15 September 2019
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Sertraline is the generic name of an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class of drugs that is occasionally given to patients suffering from attention-deficit/hyperactivity disorder (ADHD). Also known by the brand name Zoloft®, sertraline has not been approved specifically for treatment of ADHD and may have potentially serious side effects. Antidepressants like sertraline are not typically used as a treatment for ADHD, but are frequently needed to treat concurrent depression or anxiety symptoms that commonly occur in ADHD patients.

Researchers have not thoroughly researched sertraline and ADHD together. Some research has focused on sertraline and depression, but typically patients with ADHD have been excluded from the studies. One exception is a 1996 study that examined the effects of sertraline and fluoxetine on depression in patients who also had symptoms of ADHD. While all experienced an improvement in depressive symptoms, none experienced any improvement in ADHD symptoms.

The biggest concern doctors have with sertraline and ADHD or depression is an increased risk of aggression and suicidal behavior during sertraline treatment in children and adolescents. A typical adolescent has a 2-percent risk of attempting suicide. Patients who were being treated for depression with sertraline saw a jump in suicidal behavior to 3.5 to 4 percent. Some adult patients also reported an increase in aggressive and violent behavior.


In 2003, the United Kingdom banned sertraline for children less than 18 years old because of the link between sertraline and suicidal behavior. Owing to this link, many doctors warn against sertraline and ADHD, even when depression is present. In the US, the only drug approved for depression in children is fluoxetine, which is also sold under the brand name Prozac® and does not have the potential for aggressive behavior or suicide.

Still, many doctors attempt to explain away the link between sertraline and aggressive behavior. Some hypothesize that the antidepressant eased depression enough that patients who had been already considering suicide were then energized enough to carry out the action. Many others have had positive experiences with sertraline and ADHD or depression without undesirable side effects.

Considering the controversy, it may be best to avoid mixing sertraline and ADHD in children. There are other antidepressants that are more appropriate and other medications for treating ADHD symptoms. If a child is taking sertraline, it’s best to watch for any changes in behavior. These changes in behavior include aggression, violent outbursts, and increased angry episodes. Any time a child indicates that she intends to harm herself or others is a cause for concern and an issue to discuss with a physician.


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Post 3

I used sertraline for a while and it did not help with my ADHD at all. There is an issue with prescribing antidepressants to someone who has both ADHD and depression and/or anxiety symptoms. Depression and anxiety can actually be due to poorly managed ADHD. That's why when most doctors have a patient with ADHD and depression, they prescribe an ADHD medication first. It's very much possible that depression and anxiety may go away when the ADHD is under control. If it doesn't, then the doctor may consider the depression separate from ADHD.

As far as sertraline for ADHD goes though, I don't think it works. I contribute to an ADHD forum and I've not heard anyone else say that sertraline helped their ADHD. If anyone out there has had a different experience though, I would love to hear about it.

Post 2

Of course, if it has been proven that sertraline is dangerous for ADHD sufferers, it should not be used by them. But if there is no proof on this issue, then I don't see an issue with ADHD sufferers using sertraline for depression or ADHD if it helps them. Sometimes doctors give off-label drugs because they have personal experience with previous patients who have benefited. It's not an uncommon practice.

Post 1

I'm not a doctor or expert on this topic. But I have had depression and anxiety on and off in my life and have been treated with some of these medications in the past. Some doctors' explanation that sertraline treated depression enough to energize the patient into suicide seems like utter nonsense to me.

It is a well known fact that all anxiety and depression medications may increase the occurrence of suicidal thoughts. I have not come across an SSRI that doesn't mention this in the potential risks and side effect section of the drug description. And manufacturers ask patients to tell their doctor immediately to change the dose or the drug if this does indeed happen.

So it is not surprising that ADHD patients using sertraline may experience this problem. And I agree that sertraline should not be used by ADHD patients because of the greater number of side effects they experience.

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