What is the Difference Between Plasma and Serum?

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  • Written By: Dulce Corazon
  • Edited By: W. Everett
  • Last Modified Date: 26 November 2018
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Plasma and serum are both found in blood. Blood contains the red blood cells (RBC), the platelets, the white blood cells (WBC), and several other important substances, including electrolytes, fibrinogen, hormones, and antibodies. These are all suspended in the fluid portion of the blood, which is the plasma. The main difference between plasma and serum is the absence of fibrinogen, an important clotting factor, in the serum.

Neither plasma or serum contain red or while blood cells or platelets, but they contain all the other substances, except for the fibrinogen, which is not present in the serum. Inside the body, these blood components cannot be distinguished from each other, but in the laboratory, they can be separated and measured in order to help with the diagnosis and monitoring of diseases. An adequate amount of blood is usually extracted from the vein in the arm of the patient and placed in a clear test tube with the name of the patient on it. It is often accompanied by a list of laboratory tests to be done.


Certain tests may require the use of plasma for the measurement of substances contained in blood. There are also tests that require only serum, such as the test for calcium, glucose, potassium, and cholesterol. When the laboratory tests to be done require the use of serum, the blood in the test tube is frequently spun in a centrifuge, a machine used to separate the components. After spinning, a blood clot that contains the fibrinogen is often visible at the bottom of the tube, and the clear yellow liquid on top is the serum. The serum will then be separated from the clot, and be subjected to different test procedures.

When blood is exposed outside the body, its tendency is to clot due to the presence of the fibrinogen. Certain tests, such as the platelet function tests, often require the use of plasma. In order to separate the plasma from the solid components in blood and at the same time prevent it from clotting, an anticoagulant is usually added to the sample before spinning. Anticoagulants are chemicals that help prevent blood clot formation, and they are also used as medications to prevent blood from clotting inside the bloodstream.

The transparency and color of plasma and serum are usually clear and yellowish. They can, however, become cloudy due to the presence of fats or bacterial contamination. Both may also appear reddish pink, which is a sign of hemolysis or breakdown of RBC. This can occur during blood extraction or from improper handling of the blood specimen. These variations in the color can sometimes lead to the blood sample being rejected, because it can cause inaccurate test results.


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Post 4

I am a medical student and doing D.M.L.T. I want to know about the differences between the serum and the plasma.

Post 2

Can you visually tell the difference between serum and plasma?

Post 1

What are the differences in percentage of proteins in serum and plasma?

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