What Is the Difference between Omeprazole and Esomeprazole?

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  • Written By: Jay Leone
  • Edited By: M. C. Hughes
  • Last Modified Date: 23 October 2019
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Omeprazole and esomeprazole are both proton-pump inhibitors used to control and ultimately decrease the amount of acid produced in the stomach. There are only subtle differences between these two medications. While both omeprazole and esomeprazole are available by prescription, mild forms of omeprazole are available over the counter. As with any medication, a doctor should be consulted before beginning a regimen involving omeprazole or esomeprazole.

These medications are designed to block acid production in the stomach and alleviate symptoms associated with gastroesophageal reflux disease (GERD). GERD is a condition in which overproduction of stomach acid causes heartburn;the condition can potentially damage the esophagus if the constant flow of acid through the stomach does not allow adequate time for damaged tissues to heal. Both omeprazole and esomeprazole can be taken to prevent further damage to the esophagus, allowing it to heal. The drugs can also be used as treatments for stomach ulcers in certain cases.

Both meprazole and esomeprazole can be used as part of a treatment plan to prevent the return of ulcers caused by Heliobacter pylori (sometimes known as H. Pylori), a type of bacteria. In patients with Zollinger-Ellison syndrome, another disease that results in the production of too much acid, these drugs can also be effective. Non-prescription strength omeprazole is often employed to treat frequent heartburn, or heartburn that occurs twice or more daily.


Prescription omeprazole is available in delayed-release capsules as well as in packets of delayed-release granules that can be mixed with liquids and ingested. Prescription esomeprazole, however, is only available in delayed-release capsule form. These capsules can be opened and their contents mixed with liquids such as water if patients choose not to swallow them whole. Both medications are designed to be taken about an hour before a meal. Omeprazole and esomeprazole are taken between one and three times daily as outlined by a physician's treatment plan.

People who are about to begin a treatment plan involving either of these medications should be aware that they may experience some side effects. Certain side effects associated with omeprazole include fever, headache, vomiting, nausea, diarrhea, and stomach pain. Some side effects linked with esomeprazole use include dry mouth, stomach pain, nausea, diarrhea, and headache. Patients who experience an irregular heartbeat, difficulty breathing, or swelling of the tongue, lips, eyes, face or hands after taking these medications may be experiencing allergic reactions and should stop taking the medication immediately and consult a physician.


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Post 1

I have taken omeprazole in the past and did not have relief from my chest pain, so my doctor just recently prescribed nexium (esomeprazole). I am hoping this will work if there is any difference between the two. I have had major heart examination tests with normal results.

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