What Is the Difference between Lisinopril and Metoprolol?

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  • Written By: H. Lo
  • Edited By: Lauren Fritsky
  • Last Modified Date: 15 October 2019
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Lisinopril and metoprolol are both medications that treat high blood pressure. The main difference between lisinopril and metoprolol is that lisinopril is an angiotensin-converting enzyme (ACE) inhibitor while metoprolol is a beta blocker. As they are two different types of medications, lisinopril and metoprolol each help control high blood pressure through different means. Other differences between lisinopril and metoprolol include dosage, additional medical conditions they treat, and safety issues for pregnant or breastfeeding women.

High blood pressure is a medical condition in which the heart pumps blood with too much force through the arteries. An ACE inhibitor lowers blood pressure by preventing the body from producing a substance called angiotensin II. Angiotensin II makes the heart work harder and causes high blood pressure because it narrows blood vessels. A beta blocker, on the other hand, lowers blood pressure by blocking the effects that epinephrine has on the body. By blocking epinephrine, or adrenaline, a beta blocker enables the heart to beat at a slower pace, and less forcefully as well.


Lisinopril comes in tablet form and the usual prescription is to take it once a day. In addition to high blood pressure, lisinopril is also helpful in treating heart failure, when combined with other medications. Metoprolol also comes in tablet form, as well as in extended-release tablet form, with a usual prescription for the tablet being once or twice a day, and the extended-release tablet being once a day; the extended-release tablet is designed to allow the medication to release slowly into the body over a period of time, so the medication stays in the system longer. Unlike lisinopril, metoprolol needs to accompany or follow a meal. Other medical conditions that metoprolol helps treat include chest pain, heart failure and irregular heartbeat.

Pregnant or breastfeeding women should not use lisinopril. In pregnant women, lisinopril can cause the baby to have birth defects. It is not known whether lisinopril is found in breast milk, but as pregnant women should not take the medication, it is the usual recommendation that breastfeeding women not take it as well. As for metoprolol, pregnant or breastfeeding women should only take the medication if their doctor recommends it; it will depend on their condition and if it will be beneficial to the mother. This is because it is not known whether metoprolol has a negative effect on unborn babies.


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Post 3

@fify-- I'm not sure how the body responds when these are taken together. But as an athlete, I know that metoprolol prevents my heartbeat from going up too much, but lisinopril doesn't. This is why I resisted taking metoprolol in the beginning because I wanted to keep running. But my high pulse rate is more of a problem than my blood pressure, so metoprolol is the right drug for me.

Post 2

@fify-- Yes, they can be prescribed together. As you said, they do the same thing, but very differently. Depending on what a patient's blood pressure ratings and pulse are like, a doctor may want to prescribe both.

I take both of these together for high blood pressure. In terms of results, they are both effective although at times, I feel that the lisinopril works better than metoprolol. I don't know if this applies to everyone though or if it is just me.

As far as I know, lisinopril is better for high blood pressure if someone has risk of kidney damage due to diabetes or some other reason. I have type 2 diabetes in addition to high blood pressure, so maybe that's why lisinopril works better for me.

Post 1

Since lisinopril and metoprolol reduce high blood pressure through different ways, are they ever prescribed together for a high blood pressure patient? Or do they interact negatively with one another because of side effects?

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