What Is the Connection between Lisinopril and Phentermine?

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  • Written By: S. Berger
  • Edited By: Shereen Skola
  • Last Modified Date: 23 February 2020
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Lisinopril and phentermine are both commonly prescribed medications, but they are quite different in their uses and effects. Lisinopril is a type of medication known as an angiotensin converting enzyme (ACE), usually used to treat hypertension and congestive heart failure. Phentermine is a medication resembling amphetamine which is used in short-term regimens with diets and exercise to treat obesity. While lisinopril affects hormone systems in the body, ultimately allowing blood to flow through the body more easily, phentermine helps to regulate feelings of fullness in the brain.

Hypertension can result from obesity, so a medical provider may occasionally prescribe both medications simultaneously. Taking lisinopril and phentermine at the same time can increase the risk of side effects. These medications may affect different systems in the body, but their indirect effects could have unexpected consequences. Additionally, doctors may be reluctant to prescribe a stimulant like phentermine to an individual already suffering from hypertension. For both of these reasons, the combination of taking lisinopril and phentermine at the same time is relatively rare.


Usually, lisinopril is taken one time per day, in a tablet. Individuals taking this medication are advised to take it as long as it is prescribed, since it does not actually act as a cure for heart failure or hypertension, it only treats the symptoms of these diseases. Like any medication, lisinopril can cause side effects even when taken as prescribed. These side effects can include dizziness, headaches, and drowsiness. Lisinopril also has the potential to cause more serious side effects that require immediate medical care, such as chest pain and fainting, because these symptoms could indicate a heart attack.

Unlike lisinopril, phentermine can be prescribed in different dosing schedules. For the extended release version of this medication, phentermine is only taken once a day. When the immediate release version is taken, however, phentermine is taken up to three times each day, around 30 minutes prior to eating. Phentermine also has known potential side effects, but these include dry mouth and gastrointestinal problems, instead of dizziness. This medication, unlike lisinopril, can be addictive, so it is normally only prescribed for short periods of time.

Doctors usually monitor patients for different health issues with regard to lisinopril and phentermine. Individuals that take lisinopril have to undergo regular blood pressure checks to ensure the medication is working properly. Lab tests are not typically necessary for individuals taking phentermine; however, doctors will often encourage regular visits to make sure that they are losing weight.


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Post 3

@feruze-- Actually, dizziness is a possible side effect of both lisinopril and phentermine. So you might not be experiencing dizziness from their interaction but from one or both of the drugs.

Phentermine can also cause gastro-intestinal problems and dry mouth and lisinopril can also cause fatigue and headaches.

I'm taking them together as well and I think that this is a great combination for obesity related blood pressure issues. My blood pressure has gone back to normal since I started taking them and slowly I am losing weight.

I did have some side effects the first couple of weeks like fatigue and diarrhea, but later my body adjusted. You should definitely ask your doctor about side effects but it's probably a good idea to give the drugs some more time.

Post 2

@burcidi-- Yes, I'm taking lisinopril for high blood pressure and phentermine for weight and they make me extremely dizzy and nauseated. I have a doctor's appointment soon, I'm going to ask him to change one of these.

Post 1

What kind of side effects may be experienced when taking lisinopril and phentermine hydrochloride together?

My sister was prescribed both of these medications. She started taking them last week but she's worried about possible interactions.

Does anyone else take these together? Have you had any negative side effects from them?

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