What is Rosiglitazone Maleate?

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  • Written By: Stephany Seipel
  • Edited By: A. Joseph
  • Last Modified Date: 24 February 2020
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Rosiglitazone maleate is a prescription drug used to treat type 2, non-insulin-dependent diabetes. It works by increasing the patient's sensitivity to insulin and improves the body's ability to control blood sugar levels. Rosiglitazone maleate drug has several serious side effects.

This drug contains thiazolidinedione, an anti-diabetic agent that lowers the blood sugar, and it has been used to treat adult-onset diabetes. Rosiglitazone maleate does not help the body produce insulin. It is not designed to treat type 1 or insulin-dependent diabetes or to help patients who suffer from diabetic ketoacidosis.

Most patients initially take 4 milligrams a day, and the medications are adjusted as needed. The drug can be taken with or without food. Doctors occasionally prescribe rosiglitazone maleate in combination with other drugs, such as metformin and sulfonylurea, to control symptoms.

In addition to using rosiglitazone maleate, patients should also watch their weight. Cutting back on calories and engaging in regular exercise will help improve the body's sensitivity to insulin and make the medication more effective. Patients should also see their doctor regularly to have their blood glucose levels and liver function checked.


Rosiglitazone maleate increases the risk of heart failure. Patients who experience symptoms such as sudden weight gain, shortness of breath or swelling in the body should consult a doctor, because these can be symptoms of a serious medical problem. Any patient who uses insulin or nitrates along with rosiglitazone maleate is at an increased risk of a heart attack.

Patients should discuss their medical history with their doctor before taking rosiglitazone maleate products. It might be dangerous for people who suffer from insulin-dependent diabetes, liver problems, a diabetic-related eye condition called macular edema or heart failure. Women who are pregnant or breastfeeding should not use rosiglitazone maleate. The product is not recommended for use in children younger than 18 years old.

Rosiglitazone maleate increases the risk of pregnancy in pre-menopausal women by making the body resume regular ovulation, so women using this drug who do not wish to become pregnant might need to consider the use of birth control. This drug can also increase the risk of low blood sugar and anemia and can make patients more susceptible to bone fractures. Other side effects include headaches and upper respiratory infections.


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