What is Porphyria?

Niki Foster

Porphyria is a group of at least eight disorders that affect the human nervous system and skin. These disorders are usually genetic, but some people with a porphyria may not experience symptoms unless they encounter certain triggers, and others may never experience symptoms at all. It's estimated that about 1 in 25,000 people in the US have this condition, and there may be as many as 1 in 50 people with it worldwide. It can generally be diagnosed with blood, urine, and stool tests, and sometimes with an ultrasound of the abdomen.

People with acute porphyria may experience insomnia.
People with acute porphyria may experience insomnia.

Multiple Types

There are two main categories of porphyria: acute and cutaneous. Acute types can affect both the nervous system and the skin, while cutaneous types usually only affect the skin. Two specific types, variegate porphyria and hereditary coproporphyria, are considered to be both acute and cutaneous because they can affect both the nervous system and skin.

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An ultrasound may be used to diagnose porphyria.
An ultrasound may be used to diagnose porphyria.

Patients with acute porphyria may experience high blood pressure.
Patients with acute porphyria may experience high blood pressure.
Acute Cutaneous Both Acute and Cutaneous
Acute Intermittent Porphyria (AIP) Porphyria Cutanea Tarda (PCT) Variegate Porphyria
ALAD-Deficiency Porphyria (ADP) Erythropoietic Protoporphyria (EPP) Hereditary Coproporphyria
Erythropoietic Protoporphyria (EPP) or Protoporphyria
Hepatoerythropoietic Porphyria (HEP)
Phlebotomy refers to the process used by health care professional to draw blood from a patient.
Phlebotomy refers to the process used by health care professional to draw blood from a patient.


This condition can be caused by inheriting faulty genes from one parent, called autosomal dominant pattern porphyria, or by inheriting faulty genes from both parents, called autosomal recessive pattern porphyria.

Porphria disorders are usually genetic.
Porphria disorders are usually genetic.

Physiologically, this condition happens when too much of a group of chemicals called porphyrins, shown above in gray and blue, builds up in the body. Humans naturally have some porphyrins in their bodies, but they are normally converted into heme, a chemical compound that is found throughout the body. Heme is important because it is a big part of hemoglobin, which is a protein that allows blood to carry oxygen and carbon dioxide throughout the body. In those with porphyria, the body does not produce enough of at least one of the eight enzymes that convert porphyrin into heme, which leads to the build up of porphyrins.

One type of porphyria attacks women before or during menstruation.
One type of porphyria attacks women before or during menstruation.

Having a build-up or porphyrins can cause a variety of symptoms, depending on where the build-up occurs. This is why there are multiple types of the illness. For instance, in PCT, porphyrins build up primarily in the liver, while in HEP, porphyrins build up mostly in red blood cells, blood plasma, and bone marrow.

People with porphyria are often highly sensitive to sun exposure and should always wear sunscreen with a high sun protection factor (SPF).
People with porphyria are often highly sensitive to sun exposure and should always wear sunscreen with a high sun protection factor (SPF).

One type of porphyria, PCT, is typically acquired, rather than inherited, though conditions that predispose a person to PCT do run in families. PCT is a build-up of porphyrins in the liver, which can be caused by a combination of several different things, including too much iron or estrogen in the body, some viruses, and an inherited deficiency of a certain enzyme called uroporphyrinogen decarboxylase (UROD).

Attack triggers

Even when a person has this condition, he may not experience symptoms unless there is a trigger; a substance or circumstance that sets off an attack. Common triggers include:

  • Hormone fluctuations, particularly those related to estrogen. Many women with this condition experience attacks before or during menstruation or during pregnancy.
  • High iron levels.
  • A virus or infection, like hepatitis.
  • Using drugs or alcohol, and possibly smoking.
  • Some over the counter medications, including some birth controls, sedatives, barbiturates, some antibiotics, vitamins, anesthetics, and tranquilizers.


Most people with any type of porphyria do not develop symptoms. In this case, it is called latent porphyria. When symptoms do occur, they can include:

  • Extreme photosensitivity, or sensitivity to light. Those with this illness are often extremely allergic to sunlight, and can develop serious burns and itchy blisters just from walking outside. These burns and blisters are also known as photodermatitis, and often scar.
  • Urine that turns red or purple in sunlight.
  • Edema, or water retention, which leads to swelling.

Those with acute porphyrias may experience all of the above symptoms as well as:

  • Seizures.
  • Paranoia, confusion, and anxiety.
  • Hallucinations.
  • High blood pressure.
  • Insomnia.
  • Vomiting, diarrhea, and constipation.
  • Severe pain in the muscles, stomach, limbs, and back that sometimes leads to weakness.
  • Excessive sweating, and accompanying dehydration.

Sometimes other conditions can cause similar symptoms, including something called pseudoporphyria. People with pseudoporphyria are often sensitive to light and may get itchy blisters when their skin is exposed to light too. Doctors can distinguish between pseudoporphyria and the real thing with a blood or urine test.


Treatments usually center around preventing attacks and lowering the body's porphyrin levels. Preventative treatments include:

  • Identifying and avoiding triggers.
  • Minimizing stress.
  • Wearing sunscreen and covering up when going outside.
  • Taking care of illnesses and infections promptly.
  • Getting good nutrition and following a high-carbohydrate diet. High carbohydrate levels can limit porphyrin production.

  • Chloroquine and other anti-malarial drugs. Though these drugs are normally taken to prevent or treat malaria, they can absorb porphyrin and help the body get rid of it more quickly.
  • Beta carotene supplements. If taken long-term, these supplements may help increase skin's tolerance to light.
  • Phlebotomy, or drawing blood. This removes iron from the body, which temporarily leads to less porphyrin production.
  • Intravenous (IV) fluids, particularly sugars and other carbohydrates. This helps limit porphyrin production.
  • IV heme substitutes like Panhematin®.

History and Cultural References

People speculate that several well-known historic figures had porphyria, including “Mad” King George III, who was ruling the United Kingdom during the American Revolution. Though this theory was popularized and even included in the movie The Madness of King George, no conclusive evidence has been found. George III's great-great-great-grandson, Prince William of Gloucester, was diagnosed with variegated porphyria in the late 1960s. Other psychiatrists speculate that the painter Vincent van Gogh and his brother might also have had this condition.

Porphyria has also been offered as an explanation for the development of vampire and werewolf legends since it causes photosensitivity, which vampires are said to have, and sometimes causes mental breakdowns that lead to irrational behavior.

Additional Resources


www.porphyriafoundation.com — Detailed information about the specific porphyrias as well as treatments and support for those with this condition.

http://emedicine.medscape.com — General information and a diagram of heme production.

www.mayoclinic.com — A broad overview of this condition, including causes, symptoms, and treatments.

http://digestive.niddk.nih.gov — General information about the illness as well as specific information about the enzymes involved in porphyrin conversion.

www.ncbi.nlm.nih.gov — An overview of causes, symptoms, risk factors, treatments, and complications.


Video 1 — Urine from someone with this condition changing colors in the sun.

Video 2 — General information about this condition and heme conversion.

Video 3 — Further information with illustrations.

People with acute porphyria may experience hallucinations.
People with acute porphyria may experience hallucinations.

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Discussion Comments


i was given Petogen in August and since then i have been having serious bleeding disorder. i have been on my period for most of that time between then and now. is it the petogen that i was given?


from last year I was using contraceptive named Nur-Isterate. In March this year when I went to the clinic I was told that there is no Nur- Isterate, so they will give me Depo Provera. In the meantime and I must still come back after 2 months to get Nur-Isterate. I went back but they only gave me Petogen. Two months have passed and I went back hoping that they will give me Nur-Isterate but instead I got Petogen. When I got to the office I searched Petogen, just to check that the Nurses are giving me the right injection.

What I found out shocked me. In the past five months I have been complaining about having light headaches, nausea, vomiting, gained weight, my eyes can't handle light, my body is aching all the time. I feel like eating all the time.

I also found out that using this medication can cause porphyria, and for what I have gathered from your webside about porphyria, I get more nervous than I was.

I was not checked if my body will not react to the injection they gave me. I am worried.

Is the injection right for me at the moment or am I just being paranoid?

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