What is Hordenine?

Sara Schmidt
Sara Schmidt

Many bodybuilders use the compound known as hordenine as a weight loss supplement. The dietary supplement, derived from grassy plants and grains, works as a central nervous system stimulant. It is said to work by slowing the digestion of food, and stimulating the release of the hormone norepinephrine, which can help energize the body.

Hordenine is sometimes used as a bodybuilding supplement.
Hordenine is sometimes used as a bodybuilding supplement.

Chemically known as N,N-dimethyl-4-hydroxyphenylethylamine, or C10H15NO, hordenine is a phenylethylamine alkaloid, or a stimulative psychoactive chemical substance. As a central nervous system stimulant, the compound is used as a weight loss stimulant by many people. The compound is chemically related to the amino acid known as tyramine. The substance is available without a prescription from a physician. Hordenine is typically sold in capsule form.

The neurotransmitter norepinephrine can energize the body.
The neurotransmitter norepinephrine can energize the body.

Proponents and users of the substance claim that it works by stimulating the nervous system and encouraging the release of norepinephrine. Norepinephrine, a hormone, can help extract lipids, or fats, from body tissue. These loose lipids are then supposed to be easier to break down during bodybuilding or general physical exercise, being used as an energy source rather than clinging to the body's cells. Research to prove these effects as true, however, is ongoing.

Hordenine is a weight loss supplement used by bodybuilders.
Hordenine is a weight loss supplement used by bodybuilders.

Those who take the supplement also claim to have reduced appetites as a result. This claim is based on the compound's supposed ability to slow the digestion of food, making eaters feel fuller. Research on this claim is ongoing as well.

It's wise to consult a doctor before taking hordenine or any other weight loss supplement.
It's wise to consult a doctor before taking hordenine or any other weight loss supplement.

Plant sources of hordenine are plentiful. Several different types of cacti, including the Pereskia genus and Beehive cactus, are known to contain the alkaloid in small amounts. Members in the Ariocarpus cactus family contain the compound. The paddle cactus is another source.

Hordenine is commonly used as a dietary supplement that many claim can reduce one's appetite.
Hordenine is commonly used as a dietary supplement that many claim can reduce one's appetite.

Higher levels of hordenine may be found in the spineless cactus known as Peyote. The Peruvian Torch and San Pedro cacti are also good sources of the substance. The best source of the stimulant, however, is the barley seed.

The Peruvian Torch flower is a good source of hordenine.
The Peruvian Torch flower is a good source of hordenine.

In addition to being used as a dietary supplement for weight loss and bodybuilding, hordenine has other medicinal properties. It can be used as an antibacterial product. These antibiotic properties can be useful in medicine.

Pharmacists and healthcare providers can help people evaluate the safety and effectiveness of weight loss supplements.
Pharmacists and healthcare providers can help people evaluate the safety and effectiveness of weight loss supplements.

Some side effects may be experienced upon taking hordenine. Some takers of the dietary supplement may experience an increase in either or both systolic and diastolic blood pressure. Difficulty with bowel movements and heavy sweating may also occur. In most studies, side effects only occurred after a high dose or overdose of the compound was taken. Most effects are short-lived if they do occur.

Side effects of hordenine may include sweating.
Side effects of hordenine may include sweating.
Sara Schmidt
Sara Schmidt

A graduate of Southeast Missouri State University, Sara has a Master’s Degree in English, which she puts to use writing for wiseGEEK and several magazines, websites, and nonprofit organizations. She has published her own novella, and has other literary projects currently in progress. Sara’s varied interests have also led her to teach children in Spain, tutor college students, run CPR and first aid classes, and organize student retreats.

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Discussion Comments

krayphysh

Hordenine is an amazing supplement as long as you're certain to get it from the right place. Unverified sources just aren't safe. I'd recommend using Liftmode. Their hordenine comes with lab results, was nicely priced, arrived quickly, and most importantly, it works. Very well! I can verify that is does decrease appetite, and I also experience a bit of a mood improvement.

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