Health
Fact-checked

At WiseGEEK, we're committed to delivering accurate, trustworthy information. Our expert-authored content is rigorously fact-checked and sourced from credible authorities. Discover how we uphold the highest standards in providing you with reliable knowledge.

Learn more...

What Is Gianotti Crosti Syndrome?

Andy Josiah
Andy Josiah

Gianotti Crosti syndrome is a skin disorder that is most commonly associated with the hepatitis virus. The condition, however, can be caused by any of several other viruses. Gianotti Crosti syndrome is named after a pair of Italian dermatologists, Agostino Crosti and Ferdinando Gianotti, who first described it. Several alternate terms exist; they include papulovesicular acrolocated syndrome, infantile papular acrodermatitis and papular acrodermatitis of childhood.

The main cause of Gianotti Crosti syndrome is any of the three hepatitis viruses that trigger the trio of infectious diseases called hepatitis A, hepatitis B and hepatitis C. The most common virus of the three linked to Gianotti Crosti syndrome, however, is the hepatitis B virus (HBV). Other viruses implicated include the Epstein-Barr virus, enterovirus, adenovirus, echovirus and human immunodeficiency virus (HIV). Infections from bacteria such as Streptococcus and Mycoplasma pneumoniae, and immunizations for diseases such as polio, measles and influenza are also known to cause the disease.

Gianotti Crosti syndrome can be caused by hepatitis B.
Gianotti Crosti syndrome can be caused by hepatitis B.

Gianotti Crosti syndrome usually manifests as firm bumps called papules appearing on the skin. Each measuring around 0.04 to 0.39 inches (1 to 10 millimeters) in diameter, the bumps may be pruritic, or itchy, although that characteristic is rather uncommon. The papules either match the color of the skin or exhibit a brownish appearance. Later, though, the bumps, particularly the ones located on the legs, begin to turn purple, an occurrence that is attributed to capillaries leaking blood. In some cases, the rash might have a red color.

The term "hepatitis" refers to inflammation and swelling of the liver.
The term "hepatitis" refers to inflammation and swelling of the liver.

Some of the most common sites for the bumps are the face, buttocks, arms and thighs. Children between the ages of six months and 12 years constitute the main group affected by Gianotti Crosti syndrome. Additionally, physicians have theorized that papules that exclusively appear on the face might be caused by Epstein-Barr virus.

The appearance of papules as indicative of Gianotti Crosti syndrome is typically sudden. Despite this, Gianotti Crosti syndrome is considered a self-limited disease, meaning that it disappears after a certain period of time. The bumps can remain from anywhere from two weeks to four months. Also, it is classified as a harmless condition, as it does not have the ability to cause significant harm to a person's health.

Receiving a blood transfusion may increase an individual's risk of contracting hepatitis B.
Receiving a blood transfusion may increase an individual's risk of contracting hepatitis B.

Thus, treatment is rarely, if ever, necessary. Treatment is typically only used to control some of the symptoms. For instance, physicians prescribe oral antihistamines or soothing lotions to reduce itchiness. In some cases, when associated conditions develop such as strep throat, patients may be prescribed antibiotics.

Discuss this Article

Post your comments
Login:
Forgot password?
Register:
    • Gianotti Crosti syndrome can be caused by hepatitis B.
      By: alexskopje
      Gianotti Crosti syndrome can be caused by hepatitis B.
    • The term "hepatitis" refers to inflammation and swelling of the liver.
      By: maya2008
      The term "hepatitis" refers to inflammation and swelling of the liver.
    • Receiving a blood transfusion may increase an individual's risk of contracting hepatitis B.
      By: Max Tactic
      Receiving a blood transfusion may increase an individual's risk of contracting hepatitis B.
    • The Epstein-Barr virus, is implicated in some cases of Gianotti Crosti syndrome, may be spread by sharing drinks and other close contact.
      By: bokan
      The Epstein-Barr virus, is implicated in some cases of Gianotti Crosti syndrome, may be spread by sharing drinks and other close contact.