What is Filaggrin?

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  • Written By: H. Colledge
  • Edited By: Heather Bailey
  • Last Modified Date: 02 May 2020
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Filaggrin is a type of protein found in the skin. Mutation of the filaggrin gene can interfere with the skin's ability to act as a barrier. This allows water to be lost from the skin, and also means bacteria and other substances can enter, possibly leading to allergies, irritation and infection.

Having a filaggrin gene mutation has been found to be associated with atopic eczema, where patches of dry skin become itchy and inflamed, and some allergic conditions such as rhinitis, where the nasal passages are irritated. The same mutation is also present in cases of ichthyosis vulgaris, where the skin becomes dry and scaly. It is thought that allergic reactions to nickel may be due to a filaggrin gene defect, because this might lead to nickel passing into the skin more easily. Currently there is no test generally available for people to see whether they have the gene mutation, but this could change in the future.

In what is known as the granular layer of the skin, there are what are called keratohyalin granules inside the cells. These granules contain profilaggrin molecules, which are converted into filaggrin. This is then used to help create the structure of the outer layers of skin. It does this by gathering together strands of a protein known as keratin, helping to form the skeletons of skin cells into tough compact shapes. Filaggrin also helps to hold water inside skin cells, keeping the skin moisturized.

Around half of all those with the more severe forms of atopic eczema are thought to have a filaggrin deficiency, and in some cases those with the disease ichthyosis vulgaris may not have any of the protein at all. People who have atopic eczema together with the deficiency are thought to be at higher risk of developing asthma as well. Eczema may be treated by using emollients instead of soap and by regularly applying moisturizers to the skin. Sometimes steroid ointments are used if the disease flares up, and these work by decreasing inflammation. Ichthyosis is generally treated by keeping the skin hydrated using moisturizers.

In the disease known as rheumatoid arthritis, the body's immune system attacks the joints, causing damage and inflammation. People who have the disease have been found to have antibodies in their blood which target filaggrin and prevent it from functioning. Blood levels of these antibodies can be measured and used to help diagnose rheumatoid arthritis in its early stages, when it can be more difficult to distinguish it from other kinds of arthritis.

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Post 2

@JaneAir - I know a few people that have a few of these conditions too. It seems like allergies, asthma, and eczema all go together. As you said, filaggrin gene mutations could explain why.

I also think it's interesting that this gene mutation might be the cause of nickel allergies as well. Or rather, to allergic reactions to nickel. I can see why having more nickel passing through your skin would cause more of a reaction. I bet some people have mild nickel allergies, but don't know about it because their filaggrin proteins work normally!

Post 1

Wow, filaggrin is very interesting. I'm kind of surprised by the amount of different things it affects! And, reading through the article, I'm fairly certain I have a filaggrin gene mutation.

I have both asthma and eczema! I also have a ton of allergies and I get rhinitis a lot. Having a filaggin gene mutation could explain this.

Hopefully they'll come up with some kind of gene therapy to fix this. A lot of other people I know who have one of these conditions have the others too. I bet this mutation is way more common than we think!

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