What is Colpermin&Reg;?

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  • Written By: Marjorie McAtee
  • Edited By: W. Everett
  • Last Modified Date: 12 October 2019
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Colpermin is a non-prescription drug used in the treatment of irritable bowel syndrome (IBS). Colpermin capsules have a special enteric coating that allows the capsules to pass through the stomach into the small intestine before they begin to dissolve. The capsules contain peppermint oil, which acts on the muscles of the bowel to stop spasms and relieve the painful symptoms of IBS. Like other non-prescription drugs, Colpermin® may not be right for everybody. Patients are generally advised to discuss Colpermin® with a physician before using it.

The peppermint oil in Colpermin®, which forms its active ingredient, acts to relieve the symptoms of irritable bowel syndrome by relaxing the smooth muscles of the small and large intestine. Relaxing these muscles helps reduce pressure in the bowels, and relieves the painful muscle spasms that can occur with IBS. Side effects of Colpermin® can include irritation of the anal area and heartburn.


Not everyone should take Colpermin® for irritable bowel symptoms. IBS sufferers over age 40 should speak to a doctor before beginning to use Colpermin®. Women who are pregnant or plan to become pregnant should discuss using this drug with their doctors. Patients who are suffering from fatigue, weight loss, bloody stool, paleness, constipation, or vomiting may have contracted a disease other than IBS, and should consult with a physician before beginning to take Colpermin®. Those experiencing painful or difficult urination, abnormal vaginal discharge, or abnormal vaginal bleeding are also often advised to speak to a doctor before starting Colpermin®.

Patients with allergies to peanuts or soybeans are usually advised against taking Colpermin®, because it can contain these ingredients. Children under 15 years of age are often warned against taking this drug. Some people may be allergic to menthol, which occurs naturally in peppermint oil. People allergic to menthol are usually asked not to take Colpermin®.

One Colpermin® capsule is typically taken up to three times a day, or up to two capsules may be swallowed three times a day if IBS symptoms are severe. The capsules should never be broken or chewed, because breaking or chewing can damage the capsule's enteric coating and hamper its efficacy in the treatment of IBS. Colpermin® does not have any known drug interactions, and is considered safe for use by those taking other non-prescription and prescription drugs. Non-prescription medications for indigestion, however, can make Colpermin® less effective. Patients are generally advised to use non-prescription drugs for indigestion at a different time of the day from when they take Colpermin®.


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