What Is Coagulation Factor IX?

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  • Written By: H. Lo
  • Edited By: Lauren Fritsky
  • Last Modified Date: 09 August 2019
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Coagulation factor IX, also known as clotting factor IX, is a natural protein found in the human body. This protein is produced by the liver and is one of several different proteins that help the body to form blood clots. When a person has trouble normally producing this protein, it can be a health problem. Although it depends on the degree of deficiency, a person who lacks this protein cannot efficiently form blood clots. As treatment for this condition, a person can receive coagulation factor IX recombinant therapy.

The F9 gene is the gene responsible for providing the body with instructions to make coagulation factor IX. When a mutation occurs in the F9 gene, it can affect the production of the protein in different ways. Instead of normally producing the protein, for example, a mutation can cause the body to produce an abnormal form of the protein. In others, a mutation can cause the body to produce a lesser amount of the protein than normal. Also, in severe cases, the body does not produce any of the protein at all.


Coagulation factor IX deficiency is a medical condition known as hemophilia B. Hemophilia is a type of bleeding disorder in which the body is unable to efficiently control a bleeding episode because it cannot form a blood clot, or does not form a clot fast enough to stop the bleeding. Blood clotting is an important bodily response to bleeding as, without it, a person can lose too much blood. Specifically with hemophilia B, the inability to control bleeding occurs because of the abnormality or lack of coagulation factor IX. Hemophilia B most commonly occurs in males and the condition itself can be mild, moderate or severe, depending on a person’s specific condition.

Those who suffer from hemophilia B might receive recombinant coagulation factor IX therapy. Recombinant coagulation factor IX is a man-made protein that is typically administered intravenously in a medical setting such as in a doctor’s office, but a person might also use the medication at home as well. The dose that a person receives will vary because it depends on the severity of his or her own condition. As with any other medication, coagulation factor IX recombinant might cause a person to experience side effects, such as chills and nausea. Serious side effects, such as allergic reaction, fever and vomiting, are also possible and require immediate medical attention.


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