What Is Coagulation Factor IX?

H. Lo

Coagulation factor IX, also known as clotting factor IX, is a natural protein found in the human body. This protein is produced by the liver and is one of several different proteins that help the body to form blood clots. When a person has trouble normally producing this protein, it can be a health problem. Although it depends on the degree of deficiency, a person who lacks this protein cannot efficiently form blood clots. As treatment for this condition, a person can receive coagulation factor IX recombinant therapy.

Coagulation factor IX is important for blood clot formation.
Coagulation factor IX is important for blood clot formation.

The F9 gene is the gene responsible for providing the body with instructions to make coagulation factor IX. When a mutation occurs in the F9 gene, it can affect the production of the protein in different ways. Instead of normally producing the protein, for example, a mutation can cause the body to produce an abnormal form of the protein. In others, a mutation can cause the body to produce a lesser amount of the protein than normal. Also, in severe cases, the body does not produce any of the protein at all.

The natural protein coagulation factor IX assists with blood coagulation.
The natural protein coagulation factor IX assists with blood coagulation.

Coagulation factor IX deficiency is a medical condition known as hemophilia B. Hemophilia is a type of bleeding disorder in which the body is unable to efficiently control a bleeding episode because it cannot form a blood clot, or does not form a clot fast enough to stop the bleeding. Blood clotting is an important bodily response to bleeding as, without it, a person can lose too much blood. Specifically with hemophilia B, the inability to control bleeding occurs because of the abnormality or lack of coagulation factor IX. Hemophilia B most commonly occurs in males and the condition itself can be mild, moderate or severe, depending on a person’s specific condition.

Individuals with hemophilia are advised against donating blood.
Individuals with hemophilia are advised against donating blood.

Those who suffer from hemophilia B might receive recombinant coagulation factor IX therapy. Recombinant coagulation factor IX is a man-made protein that is typically administered intravenously in a medical setting such as in a doctor’s office, but a person might also use the medication at home as well. The dose that a person receives will vary because it depends on the severity of his or her own condition. As with any other medication, coagulation factor IX recombinant might cause a person to experience side effects, such as chills and nausea. Serious side effects, such as allergic reaction, fever and vomiting, are also possible and require immediate medical attention.

Hypnotherapy may be used to treat hemophilia.
Hypnotherapy may be used to treat hemophilia.

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