What Is Cloxacillin Sodium?

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  • Written By: Mary McMahon
  • Edited By: Shereen Skola
  • Last Modified Date: 23 January 2019
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Cloxacillin sodium is an antibiotic medication commonly used to treat infections with Staphylococcus bacteria. It has a low risk of side effects, except for a potentially serious allergic reaction in a small number of patients. Before someone starts using cloxacillin sodium, it is advisable to discuss medical history with a medical professional to determine if there are any obvious risk factors for a bad reaction. Another drug may need to be considered to treat the infection.

This medication is in the penicillin family, and is produced through semi-synthetic means. It works by attacking the process bacteria use to synthesize their cell walls, killing them and effectively stopping the infection. The dosage is given orally and may vary depending on the specifics of the infection and the patient’s weight. An adjustment for a patient with kidney impairment may also be necessary, as these patients can’t clear this medication as quickly and require a lower dose.

People with a history of reactions to penicillin or antibiotics in the cephalosporin family may be at risk of an allergic reaction if they take cloxacillin sodium. This reaction can include a serious rash, difficulty breathing, and intense nausea and vomiting. Immediate medical attention is required to stabilize the patient and provide supportive care, and the reaction should be noted so this and related medications can be avoided in the future.


More mild cloxacillin sodium side effects can include gastrointestinal irritation, which may cause patients to feel nauseated and can cause vomiting and diarrhea. People with ongoing bowel disorders like colitis may want to confirm that it is safe to use this medication, as it could irritate the bowel lining. In addition, patients on this antibiotic may notice some oral irritation, including a tongue furred with blackish or white material. This is not dangerous and should resolve when they stop taking the drug.

Studies on the use of this medication in pregnant women indicate that it is generally safe. Women who are pregnant or planning to get pregnant may want to discuss cloxacillin sodium with their obstetricians before starting a course of therapy, just in case a specific risk factor needs to be considered. It is also important to be aware that this medication can interact with hormonal birth control, making it less effective. Patients who want to avoid pregnancy may need to use a backup method while on this medication and for several days after they are finished.


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Post 3

I was treated for staph with this medication. It cleared it up but after a month, the infection renewed itself.

My doctor has put me on cloxacillin again. Just wondering, is it possible that cloxacillin sodium is not working?

Post 2

@ankara-- Alcohol is okay with some antibiotics but it's not acceptable with others. I'm not sure which category cloxacillin sodium is in but it's better to be safe than sorry.

Even when doctors say that you can drink while taking an antibiotic, they say to limit it to one or two light drinks. Hard liquor or drinking too many is not a good idea.

The main reason for this is because alcohol can make side effects of antibiotics worse.

Post 1

Can I drink alcohol while on cloxacillin sodium?

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