What is Atridox&Reg;?

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  • Written By: Melanie Smeltzer
  • Edited By: Daniel Lindley
  • Last Modified Date: 06 October 2019
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Atridox® is a locally applied antibiotic gel used to help treat chronic gum disease in adults. When bacteria form beneath the gum line, they can cause infection. To prevent the growth of infection-causing bacteria, this medication is placed inside the deep space that lies between the teeth and gums. It then hardens and gradually disintegrates, steadily releasing the medication into the system.

Sometimes referred to by the generic name doxycycline, this gum disease medication is a synthetic antibiotic derived from a class of broad spectrum antibiotics known as tetracycline. Atridox® works by disrupting the creation of proteins by bacteria. This interruption may help to halt the process of infection. In addition, this medication is said to increase the overall health of the gums and mouth, and potentially slow or stop the advancement of periodontal disease.

The treatment period for Atridox® is typically seven days, though the drug is said to remain active for up to 21 days. This medication begins in a gel form that is gently applied to the tiny pockets just below the gum line. It then fills up the entire pocket and hardens to a wax-like substance that stays in the mouth for seven days. During this seven-day period, patients are generally told to avoid flossing and brushing their teeth, but may be prescribed a mouthwash.


Although Atridox® is generally well received by most patients, some may experience mild side effects. These side effects can include soreness, discomfort, or sensitivity in the gums or teeth, cold-like symptoms, and headache. On rare occasions there may be more severe reactions to this medication, such as an increase in blood pressure, sunburn, a loosening of teeth, or jaw pain. Some people may also experience an allergic reaction that may appear as itching or a rash on the skin, swelling in the face or mouth, or trouble breathing. Should these severe side effects occur, it is important to contact a medical professional immediately.

Atridox® can potentially interact with other medications. For example, it may interfere with estrogen pills and patches, including birth control. Patients taking hormonal contraceptives are often advised to use a backup method of birth control during treatment. This medication may also cause skin sensitivity, and those under treatment are advised to stay out of direct sunlight, or keep well covered. Sensitivity may continue up to two weeks after treatment has ended.


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