What is Antipyrine?

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  • Written By: Jennifer Long
  • Edited By: Allegra J. Lingo
  • Last Modified Date: 30 December 2019
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Antipyrine is a type of ear infection medication. It is a combination of antipyrine and benzocaine. The combination of the two medications helps treat the pain and swelling of the middle ear that occurs as a result of an infection.

This drug is manufactured under the brand Auralgan®, and is a liquid ear drop that is applied directly to the ear canal. It uses dehydrated glycerin to hold the medications and thicken the solution. A thicker drop solution helps ensure the medication has a chance to work without leaking back out.

Many ear drops such as antipyrine do not contain antibiotics in the solution. Doctors will usually prescribe oral antibiotics to treat the infection while the drops work as a pain reliever. These drops can also be prescribed as a congestion reliever when there is an excessive build up of ear wax, which would not require antibiotic treatment.

Antipyrine does not produce many common side effects other than a stinging or burning sensation, but a slight loss of balance or dizziness may occur as a result of an ear infection. Rare side effects may occur, however, including blue tinted skin or extreme weakness and fatigue. Any of these side effects may require medical assistance. Serious side effects include rash, itching, and trouble breathing. If any of these side effects occur, immediate medical attention is necessary.


This medication should be taken only as directed. General instructions are to apply the drops to the affected ear three times a day. Avoid accidentally getting the solution in the mouth or eyes. If contact with these areas occurs, they should be rinsed thoroughly with water.

Do not allow the applicator to touch any surface, including any part of the ear. Hands should be washed before applying. Do not use the antipyrine drops if there is drainage coming from the infected ear. A doctor should be notified if the pain becomes worse.

To ensure the medication has enough time to take effect and be helpful, the affected ear should remain facing upward for at least five minutes. If the medication will be used in both ears, apply it to one ear at a time. A cotton plug moistened on one end with antipyrine will help prevent the solution from coming out and can remain in place for up to ten minutes. If the solution is uncomfortably cold, the closed bottle can be cupped in the hands to warm its contents.


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