What Is Amphetamine Salt Combo?

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  • Written By: Lee Prangnell
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  • Last Modified Date: 24 September 2019
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Amphetamine salt combo is a combination of amphetamine and dextroamphetamine salts. These salts are typically combined to create a pharmaceutical product known as Adderall XR™, which is a common treatment for attention deficit hyperactivity disorder (ADHD) and narcolepsy. The amphetamine salt combo within the Adderall XR™ is present because this is the way the drug was originally synthesized by the manufacturer. In the clinical trials conducted by the original manufacturer of Adderall XR™, this combo played a major role in the drug's efficacy for treating ADHD and narcolepsy.

Dextroamphetamine saccharate, dextroamphetamine sulfate, amphetamine aspartate monohydrate and amphetamine sulfate are the four salts present, in equal shares, within the Adderall XR™ amphetamine salt combo. Adderall XR™ is officially approved by the U.S. Food & Drug Administration (FDA) for the treatment of ADHD and narcolepsy. According to the manufacturer of Adderall XR™, the amphetamine salt combo in the drug increases overall efficacy because it makes the stimulant effect and withdrawals smoother. This is useful for the treatment of ADHD because the smoother stimulation effect is more efficacious for the hyperactivity aspect of the disorder.


Amphetamines, including amphetamine salts, are in a class of psychostimulant drugs known as phenethylamines, which have the primary side effects of psychological and physiological stimulation. This stimulation occurs because the drug increases the levels of dopamine and norepinephrine neurotransmitters in the brain. Although amphetamines are clinically proven to have therapeutic utility, there is a high potential for recreational abuse. Amphetamines are notoriously addictive because euphoria is one of their main side effects, especially in excess of the recommended medical dosage. For this reason, medical practitioners typically refrain from prescribing this drug to patients who have a history of or susceptibility to substance abuse.

Chronic use of an amphetamine salt combo can produce a variety of unwanted side effects, including loss of appetite, insomnia, weight loss, and depression. In more severe cases, a patient may experience amphetamine psychosis, which is a psychotic disorder typically characterized by paranoia, delusions, and hallucinations. Adderall XR™ is a very potent drug and has the potential to be toxic to a number of organs in the human body. If the drug is used in combination with certain other types of medication, including a monoamine oxidase inhibitor (MAOI) antidepressant, a patient may experience a potentially fatal toxic neurological reaction. Therefore, a qualified medical practitioner will always assess whether there are existing contraindications with other drugs.


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Post 5

@literally45: I take d-amphetamine salt combo and I can tell you

that the benefits far outweight any side effects he may have. He

may not have any side effects at all. It really does help al ot. I gave them a chance and I am so glad I did.

Post 4

My landlady and neighbor takes amphetamine salts and boy, you can tell when she is waiting for her prescription for such to be filled, or she is unable to get it filled for a couple days. She just crashes into depression. And more than once I have seen her so "wired up" she can't sit still or finish any task she starts, no matter how small. These times are few and far between but still, it's something to consider because once you're on it there is no going back without some consequences.

Post 3

This medication is sometimes prescribed for off-label uses. For example, I'm taking it for social anxiety and depression. It has been very helpful. I feel that it reduces my negative thoughts and makes me more confident and outgoing.

I won't be taking it for a long time though. My doctor doesn't want me to become reliant on amphetamines. So this is just for the short-term.

Post 2

@literally45-- I realize that not everyone react the same way to drugs, but I've personally not experienced any negative side effects on amphetamine salt combo.

The old version of this drug was slightly more problematic because it required taking multiple doses throughout the day. But the new version is extended release so it only requires one dose.

As for amphetamine psychosis, I think that only occurs after many years of using d-amphetamine or it happens when the drug is abused. Your son is not going to develop psychosis after taking this drug at the recommended dose for a year or two.

Post 1

My son's doctor wants him to take d-amphetamine salt combo for his ADHD. I don't want him to though because of the side effects. It sounds like the side effects outweigh the benefits. I especially don't want my son to be on something that will cause psychosis.

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