What is Acetonide Cream?

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  • Written By: Erin J. Hill
  • Edited By: Bronwyn Harris
  • Last Modified Date: 26 March 2020
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Acetonide cream is a form of topical ointment comprised of corticosteroids, which are generally synthetic in nature. Primary uses include treatment for various skin conditions, such as rashes and some fungal infections. Benefits come as a result of the treatment’s anti-inflammatory properties which act to soothe and heal skin with certain conditions.

Before acetonide cream is used, patients are advised to seek a doctor’s guidance. A proper diagnosis of any skin conditions should be made before treatment methods are tried. This helps to eliminate patients diagnosing themselves and treating an illness or condition with the wrong drug. In some cases, a serious condition could cause skin irritation, so a speedy diagnosis and treatment are essential. If a condition is found that can be easily treated with over the counter acetonide cream, a patient can then proceed.

In some cases, prescription strength acetonide cream may be given for more severe skin irritation. Most times, acetonide is recommended for the treatment of cutaneous candidiasis and other irritations and has been found to be more effective than similar medications in both mild and severe cases. This is especially true when the condition is treated early.


Side effects of acetonide cream are rare but may include skin irritation such as burning or itching, dryness, acne-like eruptions, skin atrophy, allergic reaction, redness, secondary infection, and folliculitis. These are generally rare, and in most cases acetonide and other corticosteroid-based creams are well-tolerated by people within all age groups and skin types. This is true even with prolonged or frequent usage.

Those who have had previous side effects, especially severe allergic reactions, may have a sensitivity to acetonide cream and should be given alternate treatment option. Mild reactions that do not pose any life-threatening risks may be managed if the patient will only need to use acetonide for a very limited period of time and if other treatment options are ineffective or unavailable. Signs of a severe allergic reaction, though rare, include shortness of breath, hives, dizziness, vomiting, and shock.

There are several name brand and generic versions of acetonide cream and similar products sold over the counter in most pharmacies. Patients who are currently using any other prescription or over the counter drug should consult a pharmacist before using topical creams. To avoid a severe skin or allergic reaction, patients should use a small portion of the cream on an area of skin not currently showing symptoms of a skin condition. Signs of a reaction may include irritation and eruptions, along with the severe symptoms mentioned above. Immediate medical care is needed in the case of a severe reaction.


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