What is a Neuropeptide?

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  • Written By: Liz Fernandez
  • Edited By: J.T. Gale
  • Last Modified Date: 26 April 2020
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Neuropeptides are small, protein-like molecules that help neurons communicate with each other. They contain anywhere from three to 40 amino acids and are found in the central and the peripheral nervous system. Acting as messengers in the body, these molecules perform specific functions. They influence activities in the brain and body, such as analgesia, food intake, learning and memory.

Versatility is one characteristic of neuropeptides. They can transmit signals with information in several directions and in reverse, and they can also work as hormones, neuromodulators, and neurohormones. When acting as neuromodulators, these molecules can activate and deactivate other neurotransmitters.

A person’s mood, energy level, pain, pleasure, weight, cognitive reasoning, ability to form memories, and immune system regulation are tied to neuropeptides. They can turn on cellular function in the skin. Some are pro-inflammatory or anti-inflammatory. An anti-inflammatory neuropeptide may be beneficial to the body as it reduces inflammation, increases collagen and elastin, repairs scars and wrinkles, and increases circulation. People with glowing and radiant skin generally are reaping the benefits of such molecules.

Derived from the term "endogenous morphine," endorphins are one type of neuropeptide. They act as natural pain killers by blocking Substance P in the central nervous system. Substance P is another neuropeptide that transmits pain-related information from the peripheral nervous system to the central nervous system.

Endorphins play a role in memory, learning, sexual activity, and body temperature control. Some people experience the effects of these molecules when they run — called a runner’s high. The most euphoric reaction is caused by beta-endorphin. Enzymes in the body break up endorphins, therefore making their effects short term.

Dr. Candace Pert, a psychopharmacologist and professor at Georgetown University in Washington, D.C., discovered that receptor molecules and the neuropeptides that bind to them exist in every part of the body, not just in the brain. This discovery means that they are present in the blood, muscles, bones, and organs. Many scientists believed emotions occurred as a response to a signal from the brain, but Dr. Pert's research proved that they occurred at the cellular level.

Other breakthroughs in recent research include an experiment conducted at the Toronto Hospital for Sick Children. The study demonstrated a possible link between neuropeptides and the development of type 1 diabetes. Scientists injected capsaicin, which triggers the release of these molecules, into non-obese diabetic mice that were genetically predisposed to develop type 1 diabetes. The injections killed the pancreatic sensory nerves and reduced the development of diabetes by 80%.

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