What Factors Affect Uterus Lining Thickness?

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  • Written By: N. Madison
  • Edited By: Jenn Walker
  • Last Modified Date: 06 October 2019
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Some of the most common factors that can influence uterus lining thickness include hormonal imbalances and abnormally short menstrual cycles. A woman may also experience problems with the thickness of her uterine lining because of fertility drugs she is taking or impaired blood supply to the uterus. Conditions that directly affect this reproductive organ as well as infections and scarring may play a role as well.

Among the most common problems that affect the uterus lining thickness are those that involve hormones. For reproductive health, a woman's hormones must typically stay in good balance. A woman's uterine lining may be adversely affected when levels of estrogen in her body are too low, and the hormone progesterone may affect the lining as well. For example, if a person has too little progesterone in her body, it is possible for her to develop a condition called endometrial hyperplasia, which is marked by the over-thickening of the uterine lining. Too little progesterone may also cause a woman's lining to shed too soon during her menstrual cycle.

Another issue that may affect uterus lining thickness is abnormal menstrual bleeding. When a woman's menstrual cycle is abnormally short or she experiences abnormal bleeding throughout her cycle, the lining may never grow as thick as expected. This is particularly important when a woman is trying to conceive, as a reasonably thick lining is critical for the successful implantation of a fertilized egg.


Insufficient blood flow to the uterus may also adversely affect a woman's uterus lining thickness. There are various issues that can impair blood flow to this organ. Among the most common are high blood pressure (which is also referred to as hypertension), blood clotting disorders, and sometimes a condition called polycystic ovary syndrome, which is marked by multiple ovarian cysts.

Sometimes the medications a woman uses to increase her chances of conceiving also may interfere with the thickening of the uterine lining. For example, some fertility drugs alter the processes the body goes through to produce hormones and prepare for possible pregnancy. As such, some of these drugs thin the uterine lining. This may be corrected, in some cases, by taking a different drug, by discontinuing their use, or by supplementing with extra estrogen.

Anything that adversely affects the uterus may contribute to changes in uterine lining thickness. For example, a person may have a thinned uterine lining as the result of a surgery on the uterus or a uterine infection. Scarring of the uterus may cause this issue as well.


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Post 3

@ddljohn-- As far as I know, the thickening of the uterus is one of the signs of cancer but you can't know whether that's the case or not without a biopsy.

If a woman is in menopause and has a thickening of the uterus lining, the chances of it being (or becoming cancer) is higher than women who are not in menopause yet. But if the woman hasn't entered menopause, there are plenty of reasons other than cancer for why the endometrium is getting thicker, like hormones.

There really aren't any clear cut answers to these questions. Only a doctor can answer them for the individual after doing certain tests and procedures.

Post 2

What are some diseases that might cause the thickening of uterus lining?

Will endometrial cancer make the endometrium thicker or thinner?

Post 1

I found out recently that my uterus lining is thinner than it should be. My doctor couldn't figure out the underlying reason at first but when he looked at my medical history, he realized that it's probably from hyperthyroid.

I've had hyperthyroid for several years now and experience all of its symptoms including extremely short menstrual periods. My periods used to last five days before hyperthyroid and now they only last two days. I'm sure the thyroid hormonal imbalance affects my reproductive hormones too, so that's probably another reason.

It's so crazy how a seemingly unrelated condition can lead to changes in a whole different system in the body. Everything is much more connected than we realize.

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