What Are the Most Common Midazolam Side Effects?

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  • Written By: Meshell Powell
  • Edited By: Melissa Wiley
  • Last Modified Date: 24 October 2019
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Midazolam side effects are usually mild and do not pose any significant health risks, although any new or bothersome symptoms that develop after beginning treatment with this medication should be reported to a doctor for further evaluation. Some of the most frequently reported side effects of this sedative include nausea, blurred vision, and drowsiness. More serious side effects that should be reported to a doctor right away include irregular heartbeat, seizures, and difficulty breathing. Specific questions or concerns about potential side effects should be discussed with the prescribing physician.

Drowsiness and dizziness are the most common midazolam side effects because this medication is used to help sedate patients prior to certain medical procedures or surgeries. Nausea and vomiting are also reported by many who are given this drug, and additional medications are often given in an effort to reduce the severity of these symptoms. Profuse vomiting may lead to complications such as dehydration or damage to the digestive tract. If midazolam is administered in the form of an injection, skin irritation and discomfort at the injection site are possible.

Blurred vision, dry mouth, and coughing are relatively common side effects that generally dissipate after the medication has been discontinued. Lowered potassium levels are a possible consequence of using this drug, and temporary supplementation may be required. Lack of coordination or loss of muscle control may occur, especially if too much of this medication is used and over-sedation develops.


Serious heart-related midazolam side effects have been reported when midazolam is used, so the prescribing physician should be notified of any prior history of heart disease. Irregular heartbeat, sudden blood pressure changes, or chest pain may indicate the development of potentially life-threatening complications and should be evaluated by a medical professional immediately. Seizures, uncontrollable muscle movements, or a sudden inability to speak normally are also among the possible midazolam side effects.

Allergic reactions are possible when taking any medication, including midazolam, even if the drug has been well tolerated in the past. Mild reactions may cause a rash, itching, or blisters on the skin. A more severe type of allergic reaction known as anaphylaxis has been known to cause sudden death and requires emergency medical attention. Common anaphylactic symptoms include swelling of the tongue or throat, difficulty breathing, and loss of consciousness. Other side effects are possible, so it is important to discuss any individual concerns with the supervising physician or nursing staff.


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