What Are the Most Common Clobetasol Side Effects?

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  • Written By: Meshell Powell
  • Edited By: Melissa Wiley
  • Last Modified Date: 24 October 2019
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While most people are able to use clobetasol without experiencing any negative side effects, some patients may notice abnormal symptoms after beginning treatment with this medication. Some of the most frequently reported clobetasol side effects include skin irritation, the development of stretch marks, or abnormal hair growth. More serious potential clobetasol side effects include visual disturbances, facial swelling, or changes in mood or behavior. Severe allergic reactions may occur when using this medication and require immediate medical attention. Any specific questions or concerns about possible clobetasol side effects in an individual situation should be discussed with a doctor or other medical professional.

Skin irritation is among the most common clobetasol side effects. Mild to moderate burning, stinging, and redness are usually temporary, although a doctor should be consulted if the pain becomes severe. Significant swelling or blistering at the application site may indicate the development of serious complications and should be reported to a member of the medical staff. Dry skin and changes in pigmentation may also occur when using this medication.

Stretch marks, spider veins, and excessive hair growth are relatively common clobetasol side effects and usually correct themselves after the medication has been discontinued. Acne and inflammation of the hair follicles at the site of application may occur as a result of using this drug. Preexisting skin infections may become worse instead of better when using clobetasol, so a doctor should be notified if any wounds do not seem to be healing properly.


Clobetasol side effects that should be reported to a doctor immediately include blurred vision or other visual disturbances, swelling of the face, and extreme fatigue. Mood swings or noticeable changes in behavior are serious side effects that should not be ignored. If any of these symptoms develop, the medication should be discontinued right away and the doctor should be consulted for further evaluation and advice.

A serious and potentially fatal type of allergic reaction known as anaphylaxis is among the possible clobetasol side effects. Emergency medical attention should be obtained if symptoms such as chest pain, difficulty breathing, or trouble swallowing develop. In the most severe cases, the throat may swell so much that oxygen is not able to be transported to the organs of the body. Permanent brain damage or even death may occur if quick action is not taken, and life support measures often begin in the ambulance before the patient reaches the hospital.


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