What are the Best Supplements for Fibromyalgia?

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  • Written By: A. Pasbjerg
  • Edited By: Heather Bailey
  • Last Modified Date: 08 February 2020
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People suffering from the chronic pain, depression, and insomnia associated with fibromyalgia may wish to find alternative remedies to the available medical treatments. There are several supplements for fibromyalgia which have been shown to help alleviate its symptoms. Choosing the best supplements may depend on which symptoms one is suffering from, as different vitamins, minerals, and herbs can help with different problems caused by the disease. In many cases, several types of supplements may be appropriate; often patients are encouraged to take a good multivitamin and mineral supplement or combinations of treatments.

One of the supplements for fibromyalgia recognized as having positive effects on pain and sleep problems is 5-Hydroxytryptophan, or 5-HTP. This supplement helps increase the neurotransmitter serotonin in the brain, which in turn serves to block pain signals. Patients taking 5-HTP may experience a decrease in their level of pain and are also typically able to sleep better while using it. Emotional effects of the disease, such as depression and anxiety, may also be reduced.

Another of the supplements for fibromyalgia which can help alleviate a variety of issues is S-adenosylmethionine, or SAMe. SAMe is also thought to affect neurotransmitter levels, and some studies have shown it to help fibromyalgia patients. Depression, pain, and fatigue may all be reduced by taking SAMe.


Those suffering from muscle fatigue associated with fibromyalgia may benefit from taking magnesium and malic acid. Both of these supplements help increase the amount of energy generated by cells. People who feel chronically tired or weak from their fibromyalgia may find this combination of supplements helpful.

Calcium and vitamin D are also thought to be helpful supplements for fibromyalgia. Calcium can help with muscle relaxation and also promotes healthy bone growth and strength. Vitamin D is critical for promoting the absorption of calcium.

To combat the sleep issues usually associated with fibromyalgia, melatonin may be a good choice. This supplement, which is a natural hormone, is known for encouraging sleep by promoting drowsiness and healthy sleep patterns. This can also help alleviate the fatigue many patients feel due to insomnia.

Due to the chronic and painful nature of the disease, many patients suffer from anxiety and depression. For these people, use of St. John's wort may be helpful. Many studies have shown this herb effective for reducing depression, and it is thought that this effect may help improve mood in fibromyalgia sufferers.


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