What Are the Benefits of Cyproheptadine for Appetite?

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  • Written By: Mary McMahon
  • Edited By: Shereen Skola
  • Last Modified Date: 12 April 2019
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Cyproheptadine for appetite can be highly effective in patients who have a reduced desire to eat, or need to gain weight. This medication is an antihistamine intended for the management of allergies, but can cause increased appetite as a side effect. A medical practitioner can use this in an off-label capacity to help a patient who is having trouble eating, especially if the patient is struggling to meet a recommended daily caloric allowance. It is suitable for long-term use, which can be advantageous for some patients who don’t know how long they will need to take the medication.

Studies evaluating patients who take cyproheptadine for improving appetite indicate the medication can be a very effective appetite stimulant. Patients should eat more frequently while on the drug and can gain weight. In the case of patients specifically using the medication to stimulate appetite and weight gain, it can be combined with a high-calorie diet. Those who are not using it for this purpose may need to exercise caution about eating habits to ensure that they eat an appropriate amount of food.


The side effect profile of this medication is relatively low, which offers an advantage over some other appetite stimulants. It can be safe when used for extended periods of time to stimulate a patient’s appetite and maintain high appetite levels. If side effects do develop, the patient may be evaluated to check for other causes and it may be possible to switch to another medication if the cyproheptadine for appetite is the source of the issue.

This medication is often used to manage appetite suppression caused by other medications or underlying medical conditions. Administration of cyproheptadine for appetite can be complicated because the patient may have multiple medical issues that need to be considered when calculating dosage and administration practices. The patient may be asked to regularly check in and provide information about appetite levels and side effects so the medical provider can determine if the medication is working and make adjustments to treatment if necessary.

Patients who do not experience success on cyproheptadine for appetite have some other options. These can include medications designed for a shorter duration of action that may come with higher side effect risks but can be very effective. Sometimes complementary therapy such as acupuncture is also helpful. Others may benefit from approaching the appetite problem from a different angle; if someone isn’t eating because of nausea, for example, it might be beneficial to get the nausea under better control.


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Post 3
How much weight gain can I expect with this medication? I will lose my appetite once again if I quit the medication, right?
Post 2

@ZipLine-- Yea, the doctor should have mentioned that, especially considering that this drug is used to help people gain weight.

My dad has been on chemotherapy for several months and has lost a lot of weight. He doesn't have an appetite at all and the nausea and vomiting caused by chemotherapy doesn't help. He was prescribed cyproheptadine two weeks ago so that he can eat more and it's working. He's not back to his normal weight, but he finishes most of his meals now which is great.

I can understand that this is not a desirable quality when this drug is being taken for other purposes. But it has been a God-send for my dad. My mom was so sad about him not eating well.

Post 1

This explains why my six year old son is gaining weight on this drug. He's on it for allergies and surprisingly, his doctor didn't mention anything about it stimulating appetite. But I started noticing that he is eating more.

He has gained a few pounds, still is not overweight so I'm not going to take him off the drug just yet because it is working well for allergies. But eventually, he will have to switch over if he continues to gain more weight.

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