What are Podocytes?

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  • Written By: Jessica Reed
  • Edited By: Heather Bailey
  • Last Modified Date: 09 September 2019
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Podocytes, also known as glomerular epithelial cells, are a type of cell located in the kidneys which help the kidneys filter out substances found in a person's blood. The kidneys are key to extracting waste products left in the body from food and other substances. As the blood passes through the kidneys, they filter these waste products from it and produce urine to flush the waste from the body.

The kidneys depend on nearly a million glomerulus. The glomerulus are made of thin blood vessels that carry the blood that must be filtered. The outside of each of the glomerulus is covered with a filtration membrane. This is where most of the filtering action takes place. The filtration membrane consists of three layers, one of which contains the podocytes.

A main body makes up each podocyte and thin extensions branch out from it. Several main extensions break off into what are known as "foot" extensions. The ends of these extensions, often referred to as "feet," keep the podocytes anchored to the blood vessels making up the glomerulus. The feet are responsible for more than simply holding the podocytes in place, however.


Each podocyte creates an opening or a gap between itself and the next podocyte. These gaps are like tiny slits, known as slit diaphragms, and it is here that the actual filtration takes places. Blood passes through the slit diaphragms and waste is filtered out. Podocytes are the key to creating these slits and keeping the filtration system working. Together with the glomerulus, the podocytes and other cells found in the kidneys ensure your body is functioning properly.

Problems occur when part of the filtration process is not working. If the kidneys don't filter out waste, it stays in the bloodstream and can be deadly. Diseases and genetic predispositions may cause the kidneys to start failing prematurely. The kidneys may also have a harder time working simply due to old age.

Another potential problem for the kidneys is the consumption of alcohol or drugs. These harmful substances dissolve into the blood stream and are filtered out by the kidneys to protect the consumer's body. However, if a person drinks too much alcohol for the kidneys to filter, the person risks alcohol poisoning. The kidneys, along with other organs, may be damaged by the harmful substances circulating throughout the person's body. Alcohol consumption can also lead to kidney infections even if other problems are not present.


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Post 2

I saw a TV documentary awhile back about kidney disease. They explained how the podocyte cells are clustered among a glob of tiny blood vessels. Blood enters through these blood vessels and the podocyte cells filter the waste products to be flushed out of the body.

Sometimes, when the kidney becomes diseased, proteins are able to get through the filtration system and they are flushed away in the urine. Normally, proteins are needed in the body so when they are allowed to pass out of the body, it's not a good thing.

Post 1

I know that some of the causes of poorly functioning kidneys are drinking too much alcohol, drug use, getting older, disease and genetics. Any of these can result in the podocytes becoming less efficient at filtering the blood to get rid of waste and flushing it out of the system through urine.

I would like to know if drinking a large amount of water helps the kidney's filtering system to work more efficiently and possibly prevent kidney malfunction.

Some articles and doctors say that drinking when you are thirsty is the right amount. Others claim that an adult should drink between 10 - 12 glasses of water a day. I want to do the right thing, but nobody seems to know how much water is a good amount.

I'd like to have my podocytes doing the best job they can of filtering out the bad stuff from my blood!

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