Is It OK to Combine Lisinopril and Grapefruit?

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  • Written By: B. Chisholm
  • Edited By: O. Wallace
  • Last Modified Date: 21 February 2020
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The combination of lisinopril and grapefruit may be used. While grapefruit juice may interact with other medications, it has not been reported to be a problem with lisinopril. If a person is unsure about whether or not their medications are interacting, either with each other, or with foods, they should speak to their doctor or pharmacist.

Lisinopril belongs to the class of drugs called ACE-inhibitors which lower the blood pressure. They work by blocking the enzyme called the Angiotensin Converting Enzyme (ACR), which reduces the effect of angiotensin 2 and causes widening of the blood vessels, thereby lowering blood pressure. They may also decrease the work load of the heart.

All medicines are metabolized in the body and excreted through a number of different processes involving many organs and systems. Each drug undergoes metabolism in different ways and is affected by different factors. One of the systems involved in metabolism is the Cytochrome P450 enzyme system. Many drugs and some foods or drinks, such as grapefruit juice, influence this system. Some may inhibit specific enzymes in the system, while others may induce them.


If an enzyme becomes inhibited, this may result in reduced breakdown of drugs normally metabolized by that enzyme, resulting in raised levels and a possible increase in both therapeutic effect and adverse effects. Conversely, induction of an enzyme may result in a quicker breakdown of drugs normally metabolized by that enzyme, negating or lessening its required effect. Grapefruit juice is known to inhibit some of the enzymes involved in this system.

While lisinopril and grapefruit probably don't interact and can be used together, many other medications may interact with grapefruit juice due to its inhibitory action and it should be avoided by people taking them. Lisinopril and grapefruit don't fall within this group of medicines because lisinopril's metabolism does not rely on the enzymes which are blocked by grapefruit juice.

Drugs that may interact with grapefruit juice include some cholesterol drugs like statins such as atorvastatin; some calcium channel blockers, used for blood pressure and heart conditions which include felodipine and nicardipine; and some antiretroviral drugs, for people with HIV, such as saquinavir. This is by no means a full list of the medications which should not be taken with grapefruit juice. So, while there is probably no interaction between lisinopril and grapefruit, it may likely interact with other medications taken, including complementary, homeopathic and over-the counter preparations. Advice should be obtained from a doctor or pharmacist as to whether grapefruit juice should be avoided when taking some medications.


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Post 3

@simrin-- I think your doctor is just being on the safe side. As far as I know, there is no proven interaction between lisinopril and grapefruit. But since grapefruit has been found to affect many medications, some physicians prefer that their patients not mix it with lisinopril just in case.

I think everyone should follow the advice of their physician. Our doctors know us better than strangers on the internet.

I'm on a very low dose of lisinopril and my doctor said that I can have grapefruit. I'm not a huge fan of grapefruit anyway so I have it occasionally. If my doctor told me not to eat it, I wouldn't eat it.

Post 2

I asked my doctor about this and he said that I should wait a few hours after I take my medication to eat grapefruit.

Does this mean that there might be an interaction between lisinopril and grapefruit?

Post 1

I'm so glad to know that grapefruit is okay to have while on lisinopril.

My sister is on beta-blockers for high blood pressure and she's not allowed to have any grapefruit. It prevents her medications from working and increases her blood pressure.

I thought that the same would be true for lisinopril but apparently not. I love grapefruit juice in the morning so I'm glad that I don't have to give it up.

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