Zinc oxide ointment is a topical ointment used in the treatment of diaper rash, minor skin irritations, and minor burns. In addition, zinc oxide suppositories are useful in treating the itching and burning caused by painful bowel movements and hemorrhoids. Although zine oxide ointment is ineffective in eliminating bacterial and fungal skin infections, it can provide soothing relief from pain and irritation. Zinc oxide ointment should not be used in the eyes or mouth, nor should it be used on severe burns or deep puncture wounds. Unless recommended by the physician, other types of ointment should not be applied on the same area being treated with zinc oxide ointment.

Typically, zinc oxide ointment is well tolerated and the risk of side effects is low. If, however, side effects or irritation is experienced, the patient should notify a health care provider. Some infrequent side effects of using zinc oxide ointment may be allergic reaction at the application site, and hives. Patients using zinc oxide ointment suppositories for the treatment of rectal irritation should stop using it if they develop rectal bleeding or their pain continues. Because zinc oxide ointment is considered very safe, it will typically not have any negative interaction with oral medications.

Generally, when using zinc oxide to treat skin irritations, enough of the ointment should be used to completely cover the area that needs to be treated. This ointment usually leaves behind a white residue that a patient is not able to rub in. Zinc oxide cream typically can be used as often as needed. When using the skin ointment to treat diaper rash, it should be used after every diaper change. It is of the utmost importance to apply the ointment before bedtime when a long time period between diaper changes will occur. In addition, changing a wet diaper as soon as possible will also hasten healing.

Because zinc oxide has a low incidence of adverse reactions, it can be recommended for use in all ages, however, it is not recommended for pregnant women. The U.S. Food and Drug Administration classifies zinc oxide as a category C, which indicates that the medication might be detrimental to unborn babies. It is unknown if zinc oxide ointment passes through to breast milk or if it has the ability to cause harm to the nursing baby. This ointment should never be used while pregnant or nursing a baby, and should never be used on the breast area.