My grandmother had problems in her kidney collecting duct, and she developed edema due to all the fluid retention. She experienced swelling in her arms, hands, ankles, feet, and legs at different times.
At first, she woke up with puffy bags around her eyes. Then, she started to notice she putting on weight. She had always been kind of pudgy, so she did not think much about it until she noticed a marked increase in the size of her hands, feet, and ankles. She went to her doctor, who diagnosed her with nephrotic syndrome.