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What Is the Function of the Smooth Endoplasmic Reticulum?

A plant cell diagram showing the smooth endoplasmic reticulum.
The smooth endoplasmic reticulum of liver cells metabolizes alcohol.
Mitochondria work with the smooth ER to produce steroids.
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  • Written By: T. Broderick
  • Edited By: Heather Bailey
  • Last Modified Date: 15 December 2014
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The smooth endoplasmic reticulum performs a number of important metabolic functions within the cell. The exact function changes depending on the specific cell type. When not metabolizing a compound, the smooth endoplasmic reticulum acts as a storage site until metabolism begins again. Other important functions are to detoxify compounds brought into the cell and to package newly created proteins.

The general appearance of the smooth endoplasmic reticulum is a membrane folded over on itself, a feature that greatly increases the surface area where metabolic processes can occur without taking up excess space within the cell. The organelle gets its name from its appearance under a microscope; a similar organelle, the rough endoplasmic reticulum, has a collection of granules that produce proteins. One of the primary functions of the smooth endoplasmic reticulum is to produce lipids, an essential component of a cell's outer membrane. Another function it performs in all cells is the final production of glucose, an energy storage molecule.

The smooth endoplasmic reticulum also metabolizes natural and ingested toxins in all cell types. Metabolizing naturally produced toxins is a continuous process; a cell would quickly die if this function was not carried out. The smooth endoplasmic reticulum of liver cells metabolize a commonly ingested toxin: alcohol.

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Other functions of the smooth endoplasmic reticulum depend on the cell type. In a muscle cell, for example, it is responsible for releasing calcium ions when it receives a signal that the muscle cell must contract. This function of the smooth endoplasmic reticulum is so specialized in muscle cells that the organelle has a different name: the scarcoplasmic reticulum.

Another specialized function of the smooth endoplasmic reticulum is its role in the gonads of animal species. Instead of releasing calcium ions, in these cells it assists in the last stages of steroid production. A unique feature of this process is that smooth endoplasmic reticulum and mitochondria, another organelle, work together to produce steroids. This fact is exceptional as most organelles work as independent units when maintaining the cell's life functions.

Certain genetic disorders interfere with the smooth endoplasmic reticulum. In cystic fibrosis, the body cannot properly create a certain protein. This mutated protein becomes stuck in the smooth endoplasmic reticulum during packaging and is unable to leave the cell. As a result, the lungs of a person with this condition become scarred and his or her lifespan severely shortened.

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CopperSalmon
Post 3

Yeah, it only makes sense that it would contribute to diabetes, right? I'm not a doctor or anything, but if the ER cells produce too much glucose...there it is, diabetes. So what happens if they don't produce enough?

BronzeEagle
Post 2

There was an interesting study done in 2006 concerning glucosamine induced endoplasmic reticulum dysfunction being connected to hyperglycemia in mice. I'm not sure about hypoglycemia though. I assume it would contribute. ER dysfunction is thought to contribute to many varying medical issues including diseases like Parkinson's.

SunSeal
Post 1

The article talks about the smooth endoplasmic reticulum function creating glucose. I was just wondering if a dysfunction or mutation of the reticulum plays any role in causing diabetes or hypoglycemia?

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