The corpus striatum, or simply striatum, is a structure located in the forebrain in humans and many other animals. It is part of the basal ganglia, a group of structures responsible for controlling movement that also play a role in motivation and rewards. This area of the brain is involved in movement disorders like Parkinson's disease. Research continues to be conducted into the corpus striatum and its function in the brain.

This structure is buried deep within the forebrain. The term “corpus striatum” means “striped body” and is a reference to its striped appearance. Different types of tissue are present in layers, making the structure appear to be striped in gray, white, and other colors like cream in a healthy brain. It can only be seen by dissecting the brain, although medical imaging studies can be used to approximate its shape, size, and appearance without disrupting the brain tissue.

The caudate, putamen, and internal capsule are all part of the corpus striatum, and the structure is supplied with blood by the striate artery. The corpus striatum includes very dense bundles of motor neurons and it is vulnerable to damage due to strokes and diseases that create lesions in the brain. Because so many functions are concentrated in this small area, it is a devastating location to receive a brain injury as a result of disease.

In healthy individuals, the corpus striatum regulates movement with the assistance of dense bundles of motor neurons and associated neurotransmitters. In people with movement disorders, the signals between neurons are interrupted. Some people may have jerky or erratic movements, tremors, or involuntary movements. Others may have difficulty moving at all as a result of damage to the corpus striatum.

The striate arteries are narrow and can be the site of strokes, including both hemorrhagic and ischemic strokes, characterized by bleeding and oxygen deprivation, respectively. Treating strokes in this area of the brain is challenging due to the buried nature of the arteries. The corpus striatum can also be attacked by demyelinating diseases and other conditions that create plaques and lesions in the brain and central nervous system. Lesions erode neurons, interfere with nerve conduction, and can cause significant impairment. Although the brain is adaptable and capable of rewiring many pathways over time, it needs an alternate route for these new pathways and one is not always available when the damage is located in this area of the brain.