The relationship between anxiety and dry mouth is a complex matter that involves many factors. Sometimes the body responds to stress by producing certain chemicals that can regulate saliva flow. At other times, behaviors associated with anxiety, such as heavy mouth breathing, especially during panic attacks, dry out the mouth. Alternately, the very treatments for anxiety may again affect saliva-regulating chemicals and create dry mouth.

One thing under continued study is the way stress acts on the neurotransmitter acetylcholine (ACh) and the enzyme that is produced to break down acetylcholine, called acetylcholinesterase (AChE). ACh, in part, helps to regulate saliva, but when stress is present, AChE amounts may be higher than normal and can reduce ACh amounts. This establishes a direct relationship between anxiety and dry mouth. If anxiety creates AChE, the mouth is likely to be drier.

Another way anxiety and dry mouth may show a causal connection is by the way people may breathe if they are deeply anxious. Anxious people may breath more rapidly through the mouth, and some people with panic attacks do a significant amount of rapid mouth breathing during hyperventilation. An open mouth through which air flows constantly is likely to be fairly dry, which may exacerbate a problem already present due to high AChE levels.

People also develop stress coping mechanisms that may strengthen the connection between anxiety and dry mouth. Things like smoking or drinking, create drier mouth conditions. Depending on how often these behaviors are engaged in, they may worsen not only mouth symptoms, but especially with drinking, they can worsen anxiety symptoms.

Ironically, medically accepted means of treating anxiety do little to relieve dry mouth. Anxiety and dry mouth can be connected most by prescribed medical treatments. Most drugs used to calm anxiety cause dry mouth, by acting on acetylcholine and reducing its amounts. This is true of benzodiazepines like diazepam, oxazepam, alprazolam, and clonazepam, and some of the selected serotonin reuptake inhibitors used to treat anxiety. It also applies to atypical antipsychotics that are occasionally used in severe panic disorder, obsessive-compulsive disorder, post traumatic stress syndrome, and generalized anxiety disorder.

There are some medications that can be prescribed to help moisten the mouth, and these may be of use. People can also help relieve some dry mouth symptoms by drinking plenty of liquids each day, while avoiding beverages that contain caffeine. Should anxiety and dry mouth continue to be a problem, it’s important to be regular in getting dental care. Without adequate saliva in the mouth, tooth decay occurs more readily.