It has been suggested that the death toll of the 1918 flu pandemic may have been larger due to aspirin. The suggestion does have some merit.
There is a possibility that wide usage of aspirin may have caused overdose deaths. It is suggested that it was overprescribed in the panic of the flu's wake.
Critics of this hypothesis say that it would be wrong to jump to such a conclusion. It was very disturbing seeing a disease with such a high mortality rate. Even though there may be some hints of aspirin involvement, there just isn't enough evidence.