Interesting. I'm not sure about variations between sexes, but what may be of interest is the study between those who experience acute pain versus those of us who have chronic pain.
Personally I have pain 24/7, due to ankylosing spondylitis. I aim to take as few analgesics as possible as they can affect my ability to think clearly. However, I have to balance this with sufficient pain relief to work as normally as possible. I suspect that my tolerance to pain has increased as my condition has developed. How long I will have this, I don't know.
It has been suggested that chronic pain conditions of unknown etiology such as fibromyalgia may respond to antidepressants and anti-convulsives, which seems to indicate some kind of issue with brain chemistry and how the brain interprets pain signals.