Jaundice is a condition easily recognized by its symptoms of yellowed skin and sclera (the whites of the eyes), due to an accumulation of bilirubin in the body.

Red blood cells live about 120 days then die and are flushed through the body. In this process, bilirubin is produced when the hemoglobin of red blood cells is broken down in the spleen, then carried to the liver by albumin in the blood. Here most of the bilirubin combines with glucuronide to form conjugated or direct bilirubin, then is absorbed in bile, and excreted in the feces. If a disorder prevents this process from completing itself, the yellow-colored bilirubin builds up in the system until it becomes noticeable in the mucous membranes and skin.

Jaundice is not dangerous in itself but can indicate potentially serious underlying conditions that should be diagnosed and treated by a physician.

Knowing how bilirubin is processed, causes for accumulation can be narrowed to one of three key possibilities, which create the three basic classes of jaundice:

• Pre-hepatic or hemolytic: Too many red blood cells are broken down.
• Hepatic: Liver does not process the bilirubin correctly.
• Post-hepatic or extrahepatic: Bile is unable to pass properly.

Pre-hepatic (hemolytic) jaundice is caused by any condition or disease that accelerates the breakdown of red blood cells. Malaria is one example and certain genetic deficiencies can creates conditions that lead to hemolytic jaundice, as can anemia.

Hepatic jaundice causes range from acute viral hepatitis to liver disease resulting from alcoholism. Neonatal jaundice, common in newborns, is usually brief lasting only a week or so and is thought to be a result of the still-developing physiology. Though it is usually harmless and in most cases passes on its own, any infant displaying signs of jaundice should be seen by a pediatrician. (In newborns the liver sometimes requires a week or so to adjust and jaundice may be present during this time. Though this is not due to disease, it is still considered hepatic because liver function is at the root of the condition.)

Post-hepatic (obstructive) jaundice, occurs when bile cannot drain properly to the feces. Gallstones obstructing the bile duct, other ductal obstructions and certain cancers can cause post-hepatic jaundice marked by pale stools lacking the normal pigment contained in bile.

Anyone displaying symptoms of jaundice should seek medical attention so that the underlying condition can be diagnosed and treated.