What Is Genomic DNA?
Genomic DNA is the DNA that holds the complete set of genetic data for an organism. The term “genomic DNA” is used to distinguish this type of DNA from other kinds of DNA; although many people assume that all DNA is found in the genome, this is not, in fact, the case. Plasmids, for example, contain DNA, but this DNA is not part of the genome, even though it can be inherited and passed on to future generations.
In humans, the genomic DNA spans 46 chromosomes, providing a complete set of genetic information including coding DNA which leads to the expression of genetic traits, and non-coding DNA which does not have this function. The genomic DNA of humans has been sequenced as part of the Human Genome Project, with the goal of eventually learning about the specific functions of various areas of the genome. Being able to locate specific genes and other information could be useful for diagnosis and eventual treatment of genetic conditions.
The genomic DNA of several other organisms of interest has been sequenced. Animals which are are subjects of genetic research, such as fruit flies, are popular targets for sequencing. With sequencing information in hand, researchers can identify areas in which the genomic DNA varies from individual to individual. These variations can provide keys to a deeper understanding of genetic traits, including which areas of the genome are involved in expression of particular traits, and what causes expression to go awry, resulting in congenital abnormalities.
Many organisms have a complete set of genomic DNA in almost every cell. Within the cell, different operations determine which part of the genome is active, allowing the organism to create differentiated cells and to regulate cell function. Sometimes this regulation does not go as intended, which can result in the development of malignancies and other problems as genes are not expressed properly, expressed when they should not be, or not expressed at all.
The detailed study of genomic DNA is a topic of interest around the world, with a field of study known as bioinformatics being used to analyze and quantify data obtained through the study of various genomes. Researchers can do things like manipulating genomic DNA to learn more about regulation and genome function, as well as creating genome databases which can be shared with other researchers. Collaboration can be key to solving genetic puzzles, because the vast size of the genome makes it logistically impossible for a single researcher to make much headway.
Written by S.E. Smith
