Cream of mushroom soup is a hearty, thick soup that is made with a few basic ingredients, and it can be served on its own or as a side dish. Home-cooked cream of mushroom soup is generally considered a moderately simple recipe for beginning cooks. The cream types of soup, including cream of mushroom, cream of celery and cream of tomato, are considered "comfort foods" in the United States. Commercial canned varieties of this soup are available in most areas and are often used in cooking as substitutions for other ingredients. In some cases, cream of mushroom soup is used as an ingredient in other recipes, such as green bean casserole or tuna casserole.

Traditional cream of mushroom soup is made by adding cream or milk and mushrooms to a soup roux of fat and starch, often butter and flour. The recipe is adaptable and is sometimes expanded upon to include a wide variety of mushrooms, such as portobello mushrooms or even wild-picked morels, or other vegetables. Like many cream-based soups, cream of mushroom soup can be adapted to personal tastes and preferences easily, by adding or omitting ingredients or spices in the recipe.

The simplicity of cream of mushroom soup has led to its omission from the menu of many fine dining establishments, but it can be found in the ingredients lists of many meals. Cream of mushroom soup is often used in the same manner as a remoulade sauce to accompany meats and vegetable dishes or as a thickening agent for other soups and gravies. From clam chowder and bisque to the thick gravy and sauces and hearty casseroles of comfort foods around the globe, cream of mushroom soup can be found playing a versatile role.

In the home kitchen, cream of mushroom soup can be used for a variety of purposes as well. Canned cream soups are often kept on hand for quick additions to meals or recipes. The thick and creamy soup can be used for complementing meats of nearly all varieties or as a substitution in place of water or milk in a recipe. While this type of soup is used extensively in comfort foods, such as casseroles, it can also see expanded use throughout the culinary realm, such as enriching the flavors of boxed pasta meals or being used as a sauce for meats and vegetables.