When my niece became asystolic in her hospital bed after a drug overdose, the doctor injected epinephrine directly into her chest. My aunt and I were mortified when it didn’t work at first.
We could hear them talking through the door, even though they had rushed us outside. The doctor had first ordered one milligram of epinephrine. He waited three minutes, and he could see it wasn’t working. So, he called for another milligram.
After three more minutes of inadequate response, he called for three milligrams. Finally, he had to ask for five milligrams. That jolted her back to life.
We were so overjoyed that he didn’t give up when the first few doses failed to revive her. He told us that epinephrine can be administered progressively up until 15 minutes after the asystole first occurs.