I have a friend who literally had ants in her pants one time. We were playing fetch with our dogs in a field behind her parents' house. Her dog came back without the tennis ball after one of my friend's throws, so she went to get the ball.
She retrieved the ball and was walking back to the yard when I noticed her doing this funny little hop that turned into a jumping episode, followed by screaming and then the removal of her pants. She ran back into the yard without pants and her legs were covered in fire ants.
We still laugh about that when I talk with her today and that was over 20 years ago. She was really in a bad way for a few days until the bites healed and she started to feel better.