Genetically modified organisms (GMOs) in food are concern for a number of consumers who are worried about the impact that GMOs may have on their health. As a result, many companies in the late 1990s began to apply the GMO free label, indicating that their food does not contain genetically modified organisms. A number of nations legislate labeling, and in Europe, food must be labeled to indicate whether or not it contains GMOs. In the United States, however, GMO free labeling is purely voluntary and not regulated by any governmental body or organization.

Since it is not regulated, there has been some question about the validity of the GMO free label in the US. A number of organizations have pressured the Food and Drug Administration (FDA), as well as the United States Department of Agriculture (USDA), to enact legislation governing food labeling in regards to GMOs. Many food activists want a label that is standardized, so that consumers who are concerned about this issue can be assured about the GMO content of products they purchase.

Most US consumers have foods containing GMOs in their home. The majority of corn and soybeans grown in the US have been modified, as have several other crops. Some research indicates that many processed foods contain GMO ingredients, so for consumers who are concerned about this issue, GMO free labeling would be helpful.

For consumers who want to eat natural, organic foods, knowing that the products they buy are GMO free is often very important. Although there is no federal labeling program in the US, some organic farmers and natural food producers have chosen to start their own certification programs. Getting certified through such programs can be very difficult, but many producers believe consumers will be willing to pay extra for the verification.

The harmful nature of GMOs has been questioned, especially by commercial agriculture producers and seed providers. No scientific evidence has been found to suggest that genetic modification of crops is harmful to humans. Some consumers feel that it is important to be able to make conscious choices about what they eat, however, and want the ability to choose GMO free foods if they so desire.

Some studies suggest that GMOs may be harmful to agriculture, with cloned genetically modified species harming overall biological diversity and modified genes finding their way into wild plants and non-modified crops. This is especially true in the case of corn, where GMO contamination became a major issue in the 1990s. Other research, however, indicates that genetically modified crops can be of benefit to the environment. Plants designed to be resistant to herbicides and pesticides, for example, have been seen to reduce the amount of these chemicals used by farmers on both GM and non-modified crops.