Strokes are a type of brain injury in which blood supply is interrupted to part of the brain, resulting in a loss of neurological function. Strokes are also sometimes known as cerebrovascular accidents, because strokes are related to the blood or vascular supply of the brain. Strokes can be extremely debilitating, especially to an older or already compromised patient or an individual who has already had multiple strokes. Approximately 25% of people who experience a stroke will have a recurrent incident within the next five years. Women are more likely to die of a stroke than men, and strokes are one of the leading causes of death in much of the first world.

Symptoms of stroke include numbness, stabbing pains, headaches, dizziness, and blurred vision and speech. Problems with memory, thinking, controlling emotions, and logic can also result. Stroke victims can experience weakness or paralysis on one side of the body, and many experience depression as well. Patients can reduce their risk of strokes by modifying their behavior. Smoking, diabetes, hypertension, and high cholesterol are all risk factors for stroke, and some of these can be modified with diet, exercise, behavioral therapy, and medical intervention.

There are two types of stroke: ischemic and hemorrhagic. Both cause a disruption of perfusion, or the delivery of arterial blood to surrounding tissue. The area of the brain with imperfect perfusion is no longer able to oxygenate properly, causing an ischemic cascade that damages or kills brain cells.

The ischemic cascade is a series of events that can last for hours after a stroke due to the severe neurological disruption that results when blood supply to the brain is interrupted. Because the chemical functions of brain cells are interrupted, they begin to fail and sometimes ultimately to die if the process cannot be arrested. Frequently, swelling of the brain occurs as cells break down and flood the surrounding cells with toxins created in the process.

Because brain functions are not fully understood, there are few treatments for strokes other than rehabilitation and support with recovery efforts. Sometimes, depending on the type of stroke, drugs related to blood clotting are used while the event is happening in an effort to reduce or halt its effects. It is suspected that some classes of drugs may affect the brain during ischemic cascade and might ultimately be used to stop the breakdown process as well. Prevention is the best cure, because of the irreversible affects of even a small amount of brain damage.