I did not experience any side effects from estrogen cream and it reduced my post-menopausal symptoms greatly. Before, I was constantly red and sweating from hot flashes. Estrogen cream seems to have resolved the hot flashes completely.
The cream I use is a phytoestrogen cream made from soy. It can be applied anywhere and absorbs real fast. I also like that this is available as a cream because I often forget to take pills.