My cousin has scoliosis, but they know what caused hers. She was born with a tumor the size of a grapefruit on her kidney. They had to operate on her at age six weeks and did radiation on the area. In 1961, radiation wasn't nearly as precise as it is now, and when she hit her 10-year growth spurt, it showed up. She was treated with the best therapy available at the time in Memphis, and she can walk, but has a visible hump in her back -- a C-curve. Her doctor theorized the radiation had made her spine brittle and it just couldn't support her as she grew.
She was in bed for seven weeks after her surgery. She had to lie flat, but it didn't really help all that much. Now, most doctors won't even treat her because of her back condition. It has definitely altered her life.