@pastanaga - I don't think people should stress out too much about hotel hygiene but they should also be cautious. It's all too easy to get a fungal infection in your feet from hotel bathroom floors, for example.
I've seen TV shows where they go over a hotel room with those blue lights and show how many stains and things there are around and it can be pretty disgusting.
But, I also think if you stress out about it too much, you'll never go anywhere. So, it's about finding a balance where you are comfortable with the risk.
Generally, I think that hotel prices can also be a good indication of how clean they are going to be.