@pleonasm - That could be a bit of overkill. I mean, people eat papaya all the time without having to research it first. I don't think using it topically is really all that big of a deal.
And most people will be using creams that just have papaya extract in them, which should be absolutely safe. They get tested over and over before they are released for human use, so I think you can use them without having to worry.