Moisturizing gloves are used to heal skin that is chapped or dry due to weather or daily activities, such as washing dishes. They can also be used to treat eczema, a skin condition which results in dry patches of skin that may peel or bleed. Moisturizing gloves are very effective for relieving the pain of cracked skin and cuticles.

The gloves are most effective if worn while relaxing. Moisturizing gloves typically consist of a pair of one-size-fits-all gloves, made of a spandex or nylon material that will stretch in order to accommodate large or small hands. The soft outer gloves are lined with a gel formula, which contains emollients, or skin-softening agents, and anti-oxidants. Although the formula varies depending on the manufacturer of the moisturizing gloves, typical ingredients include vitamin E oil, olive oil, or jojoba oil.

When the gloves are worn, the outer fabric serves to trap body heat inside the glove. The heat causes the pores to open, allowing the moisturizing gel to penetrate the skin. The wearer may experience an immediate improvement in skin appearance and feel after using the moisturizing gloves for an hour; however, for more serious cases, he or she may wish to wear them periodically in order to maintain moisture. They can be worn as needed for dryness or discomfort, up to two or three times a week.

Moisturizing gloves can be reused and will last for up to three months before the gel runs out. They can be washed in the washer, but putting them in the dryer will destroy the gel layer. Most manufacturers of the gloves also offer moisturizing socks, which operate in the same way. A home-made alternative to moisturizing gloves is to cover the hands with a copious amount of lotion, and then sleep in an old pair of regular gloves.