As of 2012, six of the past 14 U.S. presidents were left-handed: Barack Obama, Bill Clinton, George H.W. Bush, Gerald Ford, Harry Truman and Herbert Hoover. Ronald Reagan was said to have been ambidextrous, which would mean that half of the presidents since 1929 were left-handed, if Reagan is counted. Although it's difficult to know for sure how many presidents were left-handed before that, other presidents that are said to have been able to write with their left hands include James Garfield, who was said to be ambidextrous; and Thomas Jefferson, who was right-hand dominant but was able to write legibly with his left hand as well.
More about left-handedness: